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  Increased functional connectivity in a population at risk of developing Parkinson's disease

Binder, T., Hobert, M., Pfrommer, T., Leks, E., Granert, O., Weigl, B., et al. (2021). Increased functional connectivity in a population at risk of developing Parkinson's disease. Parkinsonism & Related Disorders, 92, 1-6. doi:10.1016/j.parkreldis.2021.09.026.

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Binder, T, Author
Hobert, MA, Author
Pfrommer, T, Author
Leks, E1, 2, Author              
Granert, O, Author
Weigl, B, Author
Ethofer, T, Author
Erb, M, Author              
Wilke, M, Author
Maetzler, W, Author
Berg, D, Author
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Background While the concept of prodromal Parkinson's disease (PD) is well established, reliable markers for the diagnosis of this disease stage are still lacking. We investigated the functional connectivity of the putamina in a resting-state functional MRI analysis in persons with at least two prodromal factors for PD, which is considered a high risk for PD (HRPD) group, in comparison to PD patients and controls. Methods We included 16 PD patients, 20 healthy controls and 20 HRPD subjects. Resting state echo planar images and anatomical T1-weighted images were acquired with a Siemens Prisma 3 T scanner. The computation of correlation maps of the left and the right putamen to the rest of the brain was done in a voxel-wise approach using the REST toolbox. Finally, group differences in the correlation maps were compared on voxel-level and summarized in cluster z-statistics. Results Compared to both PD patients and healthy controls, the HRPD group showed higher functional connectivity of both putamina to brain regions involved in execution of motion and coordination (cerebellum, vermis, pre- and postcentral gyrus, supplementary motor area) as well as the planning of movement (precuneus, cuneus, superior medial frontal lobe). Conclusions Higher functional connectivity of the putamina of HRPD subjects to other brain regions involved in motor execution and planning may indicate a compensatory mechanism. Follow-up evaluation and independent longitudinal studies should test whether our results reflect a dynamic process associated with a prodromal PD state.

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 Dates: 2021-11
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: DOI: 10.1016/j.parkreldis.2021.09.026
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Title: Parkinsonism & Related Disorders
Source Genre: Journal
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Publ. Info: Kiddlington, Oxford, U.K. : Elsevier
Pages: - Volume / Issue: 92 Sequence Number: - Start / End Page: 1 - 6 Identifier: ISSN: 1353-8020
CoNE: https://pure.mpg.de/cone/journals/resource/954925618102