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  Analytical challenges of glycosaminoglycans at biological interfaces

Szekeres, G. P., Pagel, K., & Heiner, Z. (2022). Analytical challenges of glycosaminoglycans at biological interfaces. Analytical and Bioanalytical Chemistry, 414(1), 85-93. doi:10.1007/s00216-021-03705-w.

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Szekeres, Gergő Péter1, 2, Author           
Pagel, Kevin1, 2, Author           
Heiner, Zsuzsanna3, Author
Affiliations:
1Institut für Chemie und Biochemie, Freie Universität Berlin, Arnimallee 22, 14195, Berlin, Germany, ou_persistent22              
2Molecular Physics, Fritz Haber Institute, Max Planck Society, ou_634545              
3School of Analytical Sciences Adlershof, Humboldt-Universität zu Berlin, Albert-Einstein-Straße 5-11, 12489, Berlin, Germany, ou_persistent22              

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 Abstract: The analysis of glycosaminoglycans (GAGs) is a challenging task due to their high structural heterogeneity, which results in diverse GAG chains with similar chemical properties. Simultaneously, it is of high importance to understand their role and behavior in biological systems. It has been known for decades now that GAGs can interact with lipid molecules and thus contribute to the onset of atherosclerosis, but their interactions at and with biological interfaces, such as the cell membrane, are yet to be revealed. Here, analytical approaches that could yield important knowledge on the GAG-cell membrane interactions as well as the synthetic and analytical advances that make their study possible are discussed. Due to recent developments in laser technology, we particularly focus on nonlinear spectroscopic methods, especially vibrational sum-frequency generation spectroscopy, which has the potential to unravel the structural complexity of heterogeneous biological interfaces in contact with GAGs, in situ and in real time.

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Language(s): eng - English
 Dates: 2021-08-202021-09-282021-10-142022-01
 Publication Status: Issued
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/s00216-021-03705-w
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Title: Analytical and Bioanalytical Chemistry
  Abbreviation : Anal. Bioanal. Chem.
Source Genre: Journal
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Publ. Info: Heidelberg : Springer-Verlag
Pages: 9 Volume / Issue: 414 (1) Sequence Number: - Start / End Page: 85 - 93 Identifier: ISSN: 1618-2642
CoNE: https://pure.mpg.de/cone/journals/resource/111006469468428