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  SpacePHARER: sensitive identification of phages from CRISPR spacers in prokaryotic hosts

Zhang, R., Mirdita, M., Levy Karin, E., Norroy, C., Galiez, C., & Söding, J. (2021). SpacePHARER: sensitive identification of phages from CRISPR spacers in prokaryotic hosts. Bioinformatics, 37(19), 3364-3366. doi:10.1093/bioinformatics/btab222.

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 Creators:
Zhang, R.1, Author              
Mirdita, M.1, Author              
Levy Karin, E.1, Author              
Norroy, C.1, Author              
Galiez, C.1, Author              
Söding, J.1, Author              
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1Research Group of Quantitative and Computational Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1933286              

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 Abstract: SpacePHARER (CRISPR Spacer Phage–Host Pair Finder) is a sensitive and fast tool for de novo prediction of phage–host relationships via identifying phage genomes that match CRISPR spacers in genomic or metagenomic data. SpacePHARER gains sensitivity by comparing spacers and phages at the protein level, optimizing its scores for matching very short sequences, and combining evidence from multiple matches, while controlling for false positives. We demonstrate SpacePHARER by searching a comprehensive spacer list against all complete phage genomes.

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Language(s): eng - English
 Dates: 2021-04-012021-10-01
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1093/bioinformatics/btab222
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Title: Bioinformatics
Source Genre: Journal
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Pages: - Volume / Issue: 37 (19) Sequence Number: - Start / End Page: 3364 - 3366 Identifier: -