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  The orbitofrontal cortex maps future navigational goals

Basu, R., Gebauer, R., Herfurth, T., Kolb, S., Golipour, Z., Tchumatchenko, T., et al. (2021). The orbitofrontal cortex maps future navigational goals. Nature. doi:10.1038/s41586-021-04042-9.

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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

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 Creators:
Basu, Raunak1, Author
Gebauer, Robert1, Author
Herfurth, Tim2, Author           
Kolb, Simon2, Author
Golipour, Zahra1, Author
Tchumatchenko, Tatjana2, Author           
Ito, Hiroshi1, Author           
Affiliations:
1Memory and Navigation Circuits Group, Max Planck Institute for Brain Research, Max Planck Society, ou_2461699              
2Theory of neural dynamics Group, Max Planck Institute for Brain Research, Max Planck Society, ou_2461711              

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Free keywords: neural circuits spatial memories
 Abstract: Accurate navigation to a desired goal requires consecutive estimates of spatial relationships between the current position and future destination throughout the journey. Although neurons in the hippocampal formation can represent the position of an animal as well as its nearby trajectories their role in determining the destination of the animal has been questioned. It is, thus, unclear whether the brain can possess a precise estimate of target location during active environmental exploration. Here we describe neurons in the rat orbitofrontal cortex (OFC) that form spatial representations persistently pointing to the subsequent goal destination of an animal throughout navigation. This destination coding emerges before the onset of navigation, without direct sensory access to a distal goal, and even predicts the incorrect destination of an animal at the beginning of an error trial. Goal representations in the OFC are maintained by destination-specific neural ensemble dynamics, and their brief perturbation at the onset of a journey led to a navigational error. These findings suggest that the OFC is part of the internal goal map of the brain, enabling animals to navigate precisely to a chosen destination that is beyond the range of sensory perception.

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Language(s): eng - English
 Dates: 2021-03-152021-09-202021-10-27
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41586-021-04042-9
 Degree: -

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Project name : Neural circuits for route decisions using an inter-nal metric of space in the hippocampus
Grant ID : -
Funding program : -
Funding organization : Behrens-Weise-Foundation
Project name : -
Grant ID : JPMJPR1682
Funding program : PRESTO
Funding organization : Japan Science and Technology Agency
Project name : HFSP research Grant
Grant ID : RGY0072/2018
Funding program : Human Frontier Research Grant
Funding organization : Human Frontier Science Program (HFSP)
Project name : ERC-StG NavigationCircuits
Grant ID : 714642
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)
Project name : -
Grant ID : Ref. 3.1 - USA - 1201361 - HFST-P
Funding program : AvH Fellowship
Funding organization : Alexander von Humboldt Foundation

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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238