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  Three water restriction schedules used in rodent behavioral tasks transiently impair growth and differentially evoke a stress hormone response without causing dehydration

Vasilev, D., Havel, D., Liebscher, S., Slesiona-Kuenzel, S., Logothetis, N., Schenke-Layland, K., et al. (2021). Three water restriction schedules used in rodent behavioral tasks transiently impair growth and differentially evoke a stress hormone response without causing dehydration. eNeuro, 8(6): ENEURO.0424-21.2021, pp. 1-11. doi:10.1523/ENEURO.0424-21.2021.

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Vasilev, D1, 2, Author              
Havel, D1, 2, Author              
Liebscher, S, Author
Slesiona-Kuenzel, S1, 2, Author              
Logothetis, NK1, 2, Author              
Schenke-Layland, K, Author
Totah, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Water restriction is commonly used to motivate rodents to perform behavioral tasks; however, its on hydration and stress hormone levels are unknown. Here, we report daily body weight and bi-weekly packed red blood cell volume and corticosterone in adult male rats across 80 days for three commonly used water restriction schedules. We also assessed renal adaptation to water restriction using post-mortem histological evaluation of renal medulla. A control group received ad libitum water. After one week of water restriction, rats on all restriction schedules resumed similar levels of growth relative to the control group. Nominal hydration was observed, and water restriction did not drive renal adaptation. An intermittent restriction schedule was associated with an increase in corticosterone relative to the control group. Our results suggest that the water restriction schedules used here will maintain welfare in rats. However, intermittent restriction evokes a stress response which could affect behavioral and neurobiological results. Our results also suggest that stable motivation in behavioral tasks may only be achieved after one week of restriction.

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 Dates: 2021-12
 Publication Status: Published online
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 Rev. Type: -
 Identifiers: DOI: 10.1523/ENEURO.0424-21.2021
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Title: eNeuro
Source Genre: Journal
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Publ. Info: Society for Neuroscience
Pages: - Volume / Issue: 8 (6) Sequence Number: ENEURO.0424-21.2021 Start / End Page: 1 - 11 Identifier: ISSN: 2373-2822
CoNE: https://pure.mpg.de/cone/journals/resource/106249492X