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  New structural insights into the multifunctional influenza A matrix protein 1

Peukes, J., Xiong, X., & Briggs, J. A. G. (2021). New structural insights into the multifunctional influenza A matrix protein 1. FEBS Letters, 595(20), 2535-2543. doi:10.1002/1873-3468.14194.

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1873-3468.14194.pdf (Publisher version), 6MB
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 Creators:
Peukes, Julia1, Author
Xiong, Xiaoli1, Author
Briggs, John A. G.2, Author              
Affiliations:
1external, ou_persistent22              
2Briggs, John / Cell and Virus Structure, Max Planck Institute of Biochemistry, Max Planck Society, ou_3344661              

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Free keywords: VIRUS M1 PROTEIN; NUCLEAR EXPORT; LOW PH; MEMBRANE; BINDING; RNA; RIBONUCLEOPROTEIN; ASSOCIATION; TRANSPORT; DOMAINBiochemistry & Molecular Biology; Biophysics; Cell Biology; cryo-electron tomography; enveloped virus; helical reconstruction; influenza virus; M1; matrix proteins; protein oligomerization; subtomogram averaging; virus assembly;
 Abstract: Influenza A virus matrix protein 1 (M1) is the most abundant protein within virions and functions at multiple steps of the virus life cycle, including nuclear RNA export, virus particle assembly, and virus disassembly. Two recent publications have presented the first structures of full-length M1 and show that it assembles filaments in vitro via an interface between the N- and C-terminal domains of adjacent monomers. These filaments were found to be similar to those that form the endoskeleton of assembled virions. The structures provide a molecular basis to understand the functions of M1 during the virus life cycle. Here, we compare and discuss the two structures, and explore their implications for the mechanisms by which the multifunctional M1 protein can mediate virus assembly, interact with viral ribonucleoproteins and act during infection of a new cell.

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Language(s): eng - English
 Dates: 2021
 Publication Status: Published in print
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000702717800001
DOI: 10.1002/1873-3468.14194
 Degree: -

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Project name : ERC-CoG-648432 MEMBRANEFUSION
Grant ID : 648432
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)

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Title: FEBS Letters
  Other : FEBS Lett.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 595 (20) Sequence Number: - Start / End Page: 2535 - 2543 Identifier: ISSN: 0014-5793
CoNE: https://pure.mpg.de/cone/journals/resource/954925399501