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  Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly

Leneva, N., Kovtun, O., Morado, D. R., Briggs, J. A. G., & Owen, D. J. (2021). Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly. Science Advances, 7(13): eabf8598. doi:10.1126/sciadv.abf8598.

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Genre: Journal Article

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 Creators:
Leneva, N., Author
Kovtun, O., Author
Morado, D. R., Author
Briggs, John A. G.1, Author              
Owen, D. J., Author
Affiliations:
1MRC Laboratory of Molecular Biology, External Organizations, ou_3346673              

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Free keywords: Science & Technology - Other Topics
 Abstract: Retromer is a master regulator of cargo retrieval from endosomes, which is critical for many cellular processes including signaling, immunity, neuroprotection, and virus infection. The retromer core (VPS26/VPS29/VPS35) is present on cargo-transporting, tubular carriers along with a range of sorting nexins. Here, we elucidate the structural basis of membrane tubulation and coupled cargo recognition by metazoan and fungal retromer coats assembled with the non-Bin1/Amphiphysin/Rvs (BAR) sorting nexin SNX3 using cryo-electron tomography. The retromer core retains its arched, scaffolding structure but changes its mode of membrane recruitment when assembled with different SNX adaptors, allowing cargo recognition at subunit interfaces. Thus, membrane bending and cargo incorporation can be modulated to allow retromer to traffic cargoes along different cellular transport routes.

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Language(s): eng - English
 Dates: 2021
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000633443600038
DOI: 10.1126/sciadv.abf8598
ISSN: 2375-2548
 Degree: -

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Title: Science Advances
  Alternative Title : Sci. Adv.
Source Genre: Journal
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Pages: - Volume / Issue: 7 (13) Sequence Number: eabf8598 Start / End Page: - Identifier: -