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  Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins

Erlendsson, S., Morado, D. R., Cullen, H. B., Feschotte, C., Shepherd, J. D., & Briggs, J. A. G. (2020). Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins. Nature Neuroscience, 23(2), 172-175. doi:10.1038/s41593-019-0569-y.

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 Creators:
Erlendsson, S., Author
Morado, D. R., Author
Cullen, H. B., Author
Feschotte, C., Author
Shepherd, J. D., Author
Briggs, John A. G.1, Author              
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1MRC Laboratory of Molecular Biology, External Organizations, ou_3346673              

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Free keywords: beam-induced motion cryo-em bayesian-approach gag protein rna gene Neurosciences & Neurology
 Abstract: Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.

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Language(s): eng - English
 Dates: 2020
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000507802500001
DOI: 10.1038/s41593-019-0569-y
ISSN: 1097-6256
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Title: Nature Neuroscience
  Alternative Title : Nat. Neurosci.
Source Genre: Journal
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Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 23 (2) Sequence Number: - Start / End Page: 172 - 175 Identifier: -