English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer

Pastuzyn, E. D., Day, C. E., Kearns, R. B., Kyrke-Smith, M., Taibi, A. V., McCormick, J., et al. (2018). The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer. Cell, 172(1-2), 275-288. doi:10.1016/j.cell.2017.12.024.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Pastuzyn, E. D., Author
Day, C. E., Author
Kearns, R. B., Author
Kyrke-Smith, M., Author
Taibi, A. V., Author
McCormick, J., Author
Yoder, N., Author
Belnap, D. M., Author
Erlendsson, S., Author
Morado, D. R., Author
Briggs, John A. G.1, Author           
Feschotte, C., Author
Shepherd, J. D., Author
Affiliations:
1MRC Laboratory of Molecular Biology, External Organizations, ou_3346673              

Content

show
hide
Free keywords: immunodeficiency-virus type-1 extracellular vesicles synaptic plasticity messenger-rnas transposable elements angelman syndrome nervous-system visual-cortex arc/arg3.1 schizophrenia Biochemistry & Molecular Biology Cell Biology
 Abstract: The neuronal gene Arc is essential for long-lasting information storage in the mammalian brain, mediates various forms of synaptic plasticity, and has been implicated in neurodevelopmental disorders. However, little is known about Arc's molecular function and evolutionary origins. Here, we show that Arc self-assembles into virus-like capsids that encapsulate RNA. Endogenous Arc protein is released from neurons in extracellular vesicles that mediate the transfer of Arc mRNA into new target cells, where it can undergo activity-dependent translation. Purified Arc capsids are endocytosed and are able to transfer Arc mRNA into the cytoplasm of neurons. These results showthat Arc exhibits similar molecular properties to retroviral Gag proteins. Evolutionary analysis indicates that Arc is derived from a vertebrate lineage of Ty3/gypsy retrotransposons, which are also ancestors to retroviruses. These findings suggest that Gag retroelements have been repurposed during evolution to mediate intercellular communication in the nervous system.

Details

show
hide
Language(s): eng - English
 Dates: 2018
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000419840100025
DOI: 10.1016/j.cell.2017.12.024
ISSN: 0092-8674
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cell
  Alternative Title : Cell
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 172 (1-2) Sequence Number: - Start / End Page: 275 - 288 Identifier: -