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  Deciphering the Origin and Evolution of Hepatitis B Viruses by Means of a Family of Non-enveloped Fish Viruses

Lauber, C., Seitz, S., Mattei, S., Suh, A., Beck, J., Herstein, J., et al. (2017). Deciphering the Origin and Evolution of Hepatitis B Viruses by Means of a Family of Non-enveloped Fish Viruses. Cell Host & Microbe, 22(3), 387-399. doi:10.1016/j.chom.2017.07.019.

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 Creators:
Lauber, C., Author
Seitz, S., Author
Mattei, S., Author
Suh, A., Author
Beck, J., Author
Herstein, J., Author
Borold, J., Author
Salzburger, W., Author
Kaderali, L., Author
Briggs, John A. G.1, Author           
Bartenschlager, R., Author
Affiliations:
1European Molecular Biology Laboratory, External Organizations, ou_3346677              

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Free keywords: multiple sequence alignment overlapping polymerase independent evolution genome hepadnavirus insights reveals genes hbv integration Microbiology Parasitology Virology
 Abstract: Hepatitis B viruses (HBVs), which are enveloped viruses with reverse-transcribed DNA genomes, constitute the family Hepadnaviridae. An outstanding feature of HBVs is their streamlined genome organization with extensive gene overlap. Remarkably, the similar to 1,100 bp open reading frame (ORF) encoding the envelope proteins is fully nested within the ORF of the viral replicase P. Here, we report the discovery of a diversified family of fish viruses, designated nackednaviruses, which lack the envelope protein gene, but otherwise exhibit key characteristics of HBVs including genome replication via proteinprimed reverse-transcription and utilization of structurally related capsids. Phylogenetic reconstruction indicates that these two virus families separated more than 400 million years ago before the rise of tetrapods. We show that HBVs are of ancient origin, descending from non-enveloped progenitors in fishes. Their envelope protein gene emerged de novo, leading to a major transition in viral lifestyle, followed by co-evolution with their hosts over geologic eras.

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Language(s): eng - English
 Dates: 2017
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000410565400018
DOI: 10.1016/j.chom.2017.07.019
ISSN: 1931-3128
 Degree: -

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Title: Cell Host & Microbe
  Alternative Title : Cell Host Microbe
Source Genre: Journal
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Pages: - Volume / Issue: 22 (3) Sequence Number: - Start / End Page: 387 - 399 Identifier: -