The Molecular Architecture of HIV

Briggs, John A. G.; Krausslich, H. G.

doi:10.1016/j.jmb.2011.04.021

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The Molecular Architecture of HIV

Briggs, J. A. G., & Krausslich, H. G. (2011). The Molecular Architecture of HIV. Journal of Molecular Biology, 410(4), 491-500. doi:10.1016/j.jmb.2011.04.021.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0009-70DC-1 Version Permalink: https://hdl.handle.net/21.11116/0000-0009-70DD-0

Genre: Journal Article

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Creators:
Briggs, John A. G.¹, Author
Krausslich, H. G.², Author

Affiliations:
1European Molecular Biology Laboratory, External Organizations, ou_3346677
2Max Planck Society, ou_persistent13

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Free keywords: human immunodeficiency virus assembly maturation Gag capsid human-immunodeficiency-virus vitro assembly properties type-1 capsid protein in-vitro gag protein electron cryotomography nucleocapsid proteins particle-production cleavage sites matrix protein Biochemistry & Molecular Biology

Abstract: Assembly of human immunodeficiency virus type 1 is driven by oligomerization of the Gag polyprotein at the plasma membrane of an infected cell, leading to membrane envelopment and budding of an immature virus particle. Proteolytic cleavage of Gag at five positions subsequently causes a dramatic rearrangement of the interior virion organization to form an infectious particle. Within the mature virus, the genome is encased within a conical capsid core. Here, we describe the molecular architecture of the virus assembly site, the immature virus, the maturation intermediates and the mature virus core and highlight recent advances in our understanding of these processes from electron microscopy and X-ray crystallography studies. (C) 2011 Elsevier Ltd. All rights reserved.

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Language(s): eng - English

Dates: Date issued: 2011

Publication Status: Issued

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Identifiers: Other: WOS:000293674000002
DOI: 10.1016/j.jmb.2011.04.021
ISSN: 0022-2836

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Title: Journal of Molecular Biology

Alternative Title : J. Mol. Biol.

Source Genre: Journal

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Pages: - Volume / Issue: 410 (4) Sequence Number: - Start / End Page: 491 - 500 Identifier: -