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  Virological Synapse-Mediated Spread of Human Immunodeficiency Virus Type 1 between T Cells Is Sensitive to Entry Inhibition

Martin, N., Welsch, S., Jolly, C., Briggs, J. A. G., Vaux, D., & Sattentau, Q. J. (2010). Virological Synapse-Mediated Spread of Human Immunodeficiency Virus Type 1 between T Cells Is Sensitive to Entry Inhibition. Journal of Virology, 84(7), 3516-3527. doi:10.1128/jvi.02651-09.

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Genre: Journal Article

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 Creators:
Martin, N., Author
Welsch, S., Author
Jolly, C., Author
Briggs, John A. G.1, Author           
Vaux, D., Author
Sattentau, Q. J., Author
Affiliations:
1European Molecular Biology Laboratory, External Organizations, ou_3346677              

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Free keywords: neutralizing antibodies hiv-1 transmission early events infection lymphocytes coreceptors resistant ccr5 cd4 visualization Virology
 Abstract: Human immunodeficiency virus type 1 (HIV-1) can disseminate between CD4(+) T cells via diffusion-limited cell-free viral spread or by directed cell-cell transfer using virally induced structures termed virological synapses. Although T-cell virological synapses have been well characterized, it is unclear whether this mode of viral spread is susceptible to inhibition by neutralizing antibodies and entry inhibitors. We show here that both cell-cell and cell-free viral spread are equivalently sensitive to entry inhibition. Fluorescence imaging analysis measuring virological synapse lifetimes and inhibitor time-of-addition studies implied that inhibitors can access preformed virological synapses and interfere with HIV-1 cell-cell infection. This concept was supported by electron tomography that revealed the T-cell virological synapse to be a relatively permeable structure. Virological synapse-mediated HIV-1 spread is thus efficient but is not an immune or entry inhibitor evasion mechanism, a result that is encouraging for vaccine and drug design.

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Language(s): eng - English
 Dates: 2010
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000275307400036
DOI: 10.1128/jvi.02651-09
ISSN: 0022-538X
 Degree: -

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Title: Journal of Virology
  Alternative Title : J. Virol.
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 84 (7) Sequence Number: - Start / End Page: 3516 - 3527 Identifier: -