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  The Somatosensory World of the African Naked Mole-Rat

Lewin, G. R., Smith, E. S. J., Reznick, J., Debus, K., Barker, A. J., & Park, T. J. (2021). The Somatosensory World of the African Naked Mole-Rat. In R. Buffenstein (Ed.), The Extraordinary Biology of the Naked Mole-Rat. Advances in Experimental Medicine and Biology (pp. 197-220). Springer, Cham. doi:10.1007/978-3-030-65943-1_7.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0009-7377-0 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0009-7378-F
Genre: Buchkapitel

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externe Referenz:
https://pubmed.ncbi.nlm.nih.gov/34424517/ (beliebiger Volltext)
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Urheber

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 Urheber:
Lewin, Gary R 1, Autor
Smith, Ewan St J 2, Autor
Reznick, Jane 3, Autor
Debus, Karlien 1, Autor
Barker, Alison Joyce4, Autor           
Park , Thomas J 5, Autor
Affiliations:
1Molecular Physiology of Somatic Sensation, Max Delbrück Center for Molecular Medicine, Berlin, Germany, ou_persistent22              
2Department of Pharmacology, University of Cambridge, Cambridge, UK., ou_persistent22              
3Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., ou_persistent22              
4Social Systems and Circuits Group, Max Planck Institute for Brain Research, Max Planck Society, ou_3334049              
5Laboratory of Integrative Neuroscience, Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL, USA., ou_persistent22              

Inhalt

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Schlagwörter: African mole-rats; Evolution; Ion channels; Nociception; Pain.
 Zusammenfassung: The naked mole-rat (Heterocephalus glaber) is famous for its longevity and unusual physiology. This eusocial species that lives in highly ordered and hierarchical colonies with a single breeding queen, also discovered secrets enabling somewhat pain-free living around 20 million years ago. Unlike most mammals, naked mole-rats do not feel the burn of chili pepper's active ingredient, capsaicin, nor the sting of acid. Indeed, by accumulating mutations in genes encoding proteins that are only now being exploited as targets for new pain therapies (the nerve growth factor receptor TrkA and voltage-gated sodium channel, NaV1.7), this species mastered the art of analgesia before humans evolved. Recently, we have identified pain-insensitivity as a trait shared by several closely related African mole-rat species. In this chapter we will show how African mole-rats have evolved pain insensitivity as well as discussing what the proximate factors may have been that led to the evolution of pain-free traits.

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Sprache(n): eng - English
 Datum: 2021-08-24
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1007/978-3-030-65943-1_7
PMID: 34424517
 Art des Abschluß: -

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Quelle 1

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Titel: The Extraordinary Biology of the Naked Mole-Rat. Advances in Experimental Medicine and Biology
Genre der Quelle: Buch
 Urheber:
Buffenstein, Rochelle , Herausgeber
Park, Thomas J. , Autor
Holmes, Melissa M. , Autor
Affiliations:
-
Ort, Verlag, Ausgabe: Springer, Cham
Seiten: - Band / Heft: 1319 Artikelnummer: - Start- / Endseite: 197 - 220 Identifikator: ISBN: 978-3-030-65942-4