English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The HB40-JUB1 transcriptional regulatory network controls gibberellin homeostasis in Arabidopsis

Dong, S., Tarkowska, D., Sedaghatmehr, M., Welsch, M., Gupta, S., Mueller-Roeber, B., et al. (2021). The HB40-JUB1 transcriptional regulatory network controls gibberellin homeostasis in Arabidopsis. Molecular Plant. doi:10.1016/j.molp.2021.10.007.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Dong, S.1, Author              
Tarkowska, Danuse2, Author
Sedaghatmehr, M.1, Author              
Welsch, M.3, Author              
Gupta, S.4, Author              
Mueller-Roeber, B.3, Author              
Balazadeh, S.1, Author              
Affiliations:
1Stress Control Networks, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_2435691              
2external, ou_persistent22              
3Plant Signalling, Cooperative Research Groups, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753311              
4Intercellular Macromolecular Transport, Department Stitt, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753331              

Content

show
hide
Free keywords: Arabidopsis, growth, gibberellin, homeostasis, transcription factor, HB40, JUB1, GA 2-oxidase, DELLA proteins
 Abstract: ABSTRACT The phytohormones gibberellins (GAs) play fundamental roles in almost every aspect of plant growth and development. Although there is good knowledge about GA biosynthetic and signaling pathways, factors contributing to the mechanisms homeostatically controlling GA levels remain largely unclear. Here, we demonstrate that homeobox transcription factor HB40 of the HD-Zip family in Arabidopsis thaliana regulates GA content at two additive control levels. We show that HB40 expression is induced by GA and in turn reduces the levels of endogenous bioactive GAs by a simultaneous reduction of GA biosynthesis and increased GA deactivation. Hence, HB40 overexpression leads to typical GA-deficiency traits, such as small rosettes, reduced plant height, delayed flowering, and male sterility. In contrast, a loss-of-function hb40 mutation enhances GA-controlled growth. Genome-wide RNA-sequencing combined with molecular-genetic analyses revealed that HB40 directly activates transcription of JUNGBRUNNEN1 (JUB1), a key TF repressing growth by suppressing GA biosynthesis and signaling. HB40 also activates genes encoding GA 2-oxidases (GA2oxs) which are major GA catabolic enzymes. The effect of HB40 is ultimately mediated through induction of nuclear growth-repressing DELLA proteins. Our results thus uncover an important role of the HB40/JUB1/GA2ox/DELLA regulatory network in controlling GA homeostasis during plant growth.

Details

show
hide
Language(s): eng - English
 Dates: 2021-10-30
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.molp.2021.10.007
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Molecular Plant
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Oxford University Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1674-2052
CoNE: https://pure.mpg.de/cone/journals/resource/1674-2052