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  The HB40-JUB1 transcriptional regulatory network controls gibberellin homeostasis in Arabidopsis

Dong, S., Tarkowska, D., Sedaghatmehr, M., Welsch, M., Gupta, S., Mueller-Roeber, B., et al. (2022). The HB40-JUB1 transcriptional regulatory network controls gibberellin homeostasis in Arabidopsis. Molecular Plant, 15, 322-339. doi:10.1016/j.molp.2021.10.007.

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 Urheber:
Dong, S.1, Autor           
Tarkowska, Danuse2, Autor
Sedaghatmehr, M.1, Autor           
Welsch, M.3, Autor           
Gupta, S.2, Autor
Mueller-Roeber, B.3, Autor           
Balazadeh, S.1, Autor           
Affiliations:
1Stress Control Networks, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_2435691              
2external, ou_persistent22              
3Plant Signalling, Cooperative Research Groups, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753311              

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Schlagwörter: Arabidopsis, growth, gibberellin, homeostasis, transcription factor, HB40, JUB1, GA 2-oxidase, DELLA proteins
 Zusammenfassung: ABSTRACT
The phytohormones gibberellins (GAs) play fundamental roles in almost every aspect of plant growth and development. Although there is good knowledge about GA biosynthetic and signaling pathways, factors contributing to the mechanisms homeostatically controlling GA levels remain largely unclear. Here, we demonstrate that homeobox transcription factor HB40 of the HD-Zip family in Arabidopsis thaliana regulates GA content at two additive control levels. We show that HB40 expression is induced by GA and in turn reduces the levels of endogenous bioactive GAs by a simultaneous reduction of GA biosynthesis and increased GA deactivation. Hence, HB40 overexpression leads to typical GA-deficiency traits, such as small rosettes, reduced plant height, delayed flowering, and male sterility. In contrast, a loss-of-function hb40 mutation enhances GA-controlled growth. Genome-wide RNA-sequencing combined with molecular-genetic analyses revealed that HB40 directly activates transcription of JUNGBRUNNEN1 (JUB1), a key TF repressing growth by suppressing GA biosynthesis and signaling. HB40 also activates genes encoding GA 2-oxidases (GA2oxs) which are major GA catabolic enzymes. The effect of HB40 is ultimately mediated through induction of nuclear growth-repressing DELLA proteins. Our results thus uncover an important role of the HB40/JUB1/GA2ox/DELLA regulatory network in controlling GA homeostasis during plant growth.

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Sprache(n): eng - English
 Datum: 2021-10-302022-02-07
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1016/j.molp.2021.10.007
 Art des Abschluß: -

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Titel: Molecular Plant
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Oxford University Press
Seiten: - Band / Heft: 15 Artikelnummer: - Start- / Endseite: 322 - 339 Identifikator: ISSN: 1674-2052
CoNE: https://pure.mpg.de/cone/journals/resource/1674-2052