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  Origins and mechanisms leading to aneuploidy in human eggs

Wartosch, L., Schindler, K., Schuh, M., Gruhn, J. R., Hoffmann, E., McCoy, R. C., et al. (2021). Origins and mechanisms leading to aneuploidy in human eggs. Prenatal diagnosis, 41(5), 620-630. doi:10.1002/pd.5927.

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Wartosch, L.1, Author              
Schindler, K., Author
Schuh, M.1, Author              
Gruhn, J. R., Author
Hoffmann, E.R., Author
McCoy, R. C., Author
Xing, J., Author
Affiliations:
1Department of Meiosis, MPI for Biophysical Chemistry, Max Planck Society, ou_2205654              

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 Abstract: The gain or loss of a chromosome—or aneuploidy—acts as one of the major triggers for infertility and pregnancy loss in humans. These chromosomal abnormalities affect more than 40% of eggs in women at both ends of the age spectrum, that is, young girls as well as women of advancing maternal age. Recent studies in human oocytes and embryos using genomics, cytogenetics, and in silico modeling all provide new insight into the rates and potential genetic and cellular factors associated with aneuploidy at varying stages of development. Here, we review recent studies that are shedding light on potential molecular mechanisms of chromosome missegregation in oocytes and embryos across the entire female reproductive life span.

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Language(s): eng - English
 Dates: 2021-03-222021-04
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/pd.5927
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Title: Prenatal diagnosis
Source Genre: Journal
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Pages: - Volume / Issue: 41 (5) Sequence Number: - Start / End Page: 620 - 630 Identifier: -