English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Impairment of hypoxic pulmonary vasoconstriction in acute respiratory distress syndrome

Gierhardt, M., Pak, O., Walmrath, D., Seeger, W., Grimminger, F., Ghofrani, H. A., et al. (2021). Impairment of hypoxic pulmonary vasoconstriction in acute respiratory distress syndrome. EUROPEAN RESPIRATORY REVIEW, 30(161): 210059. doi:10.1183/16000617.0059-2021.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Gierhardt, Mareike1, Author              
Pak, Oleg, Author
Walmrath, Dieter, Author
Seeger, Werner1, Author              
Grimminger, Friedrich, Author
Ghofrani, Hossein A., Author
Weissmann, Norbert, Author
Hecker, Matthias, Author
Sommer, Natascha, Author
Affiliations:
1Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591698              

Content

show
hide
Free keywords: -
 Abstract: Acute respiratory distress syndrome (ARDS) is a serious complication of severe systemic or local pulmonary inflammation, such as caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. ARDS is characterised by diffuse alveolar damage that leads to protein-rich pulmonary oedema, local alveolar hypoventilation and atelectasis. Inadequate perfusion of these areas is the main cause of hypoxaemia in ARDS. High perfusion in relation to ventilation (V/Q<1) and shunting (V/Q=0) is not only caused by impaired hypoxic pulmonary vasoconstriction but also redistribution of perfusion from obstructed lung vessels. Rebalancing the pulmonary vascular tone is a therapeutic challenge. Previous clinical trials on inhaled vasodilators (nitric oxide and prostacyclin) to enhance perfusion to high V/Q areas showed beneficial effects on hypoxaemia but not on mortality. However, specific patient populations with pulmonary hypertension may profit from treatment with inhaled vasodilators. Novel treatment targets to decrease perfusion in low V/Q areas include epoxyeicosatrienoic acids and specific leukotriene receptors. Still, lung protective ventilation and prone positioning arc the best available standard of care. This review focuses on disturbed perfusion in ARDS and aims to provide basic scientists and clinicians with an overview of the vascular alterations and mechanisms of V/Q mismatch, current therapeutic strategies, and experimental approaches.

Details

show
hide
Language(s):
 Dates: 2021-09-152021-09-30
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000711927400005
DOI: 10.1183/16000617.0059-2021
PMID: 34526314
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: EUROPEAN RESPIRATORY REVIEW
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 30 (161) Sequence Number: 210059 Start / End Page: - Identifier: ISSN: 0905-9180