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  Structural connectivity-based segmentation of the human entorhinal cortex

Framås Syversen, I., Witter, M. P., Kobro-Flatmoen, A., Goa, P. E., Navarro Schröder, T., & Doeller, C. F. (2021). Structural connectivity-based segmentation of the human entorhinal cortex. NeuroImage, 245: 118723. doi:10.1016/j.neuroimage.2021.118723.

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 Creators:
Framås Syversen, Ingrid1, Author
Witter, Menno P.1, Author
Kobro-Flatmoen, Asgeir1, Author
Goa, Pål Erik2, Author
Navarro Schröder, Tobias1, Author
Doeller, Christian F.1, 3, 4, Author              
Affiliations:
1Kavli Institute for Systems Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway, ou_persistent22              
2Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway, ou_persistent22              
3Department Psychology (Doeller), MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2591710              
4Institute of Psychology, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Magnetic resonance imaging; Diffusion tensor imaging; Structural connectivity; Medial entorhinal cortex; Lateral entorhinal cortex; Segmentation
 Abstract: The medial (MEC) and lateral entorhinal cortex (LEC), widely studied in rodents, are well defined and characterized. In humans, however, the exact locations of their homologues remain uncertain. Previous functional magnetic resonance imaging (fMRI) studies have subdivided the human EC into posteromedial (pmEC) and anterolateral (alEC) parts, but uncertainty remains about the choice of imaging modality and seed regions, in particular in light of a substantial revision of the classical model of EC connectivity based on novel insights from rodent anatomy. Here, we used structural, not functional imaging, namely diffusion tensor imaging (DTI) and probabilistic tractography to segment the human EC based on differential connectivity to other brain regions known to project selectively to MEC or LEC. We defined MEC as more strongly connected with presubiculum and retrosplenial cortex (RSC), and LEC as more strongly connected with distal CA1 and proximal subiculum (dCA1pSub) and lateral orbitofrontal cortex (OFC). Although our DTI segmentation had a larger medial-lateral component than in the previous fMRI studies, our results show that the human MEC and LEC homologues have a border oriented both towards the posterior-anterior and medial-lateral axes, supporting the differentiation between pmEC and alEC.

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Language(s): eng - English
 Dates: 2021-10-222021-07-302021-11-112021-11-122021-12-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuroimage.2021.118723
Other: Online ahead of print
PMID: 34780919
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Project name : -
Grant ID : ERC-CoG GEOCOG 724836
Funding program : -
Funding organization : European Research Council
Project name : -
Grant ID : 223262/F50
Funding program : -
Funding organization : Research Council of Norway
Project name : -
Grant ID : 197467/F50
Funding program : -
Funding organization : National Infrastructure scheme of the Research Council of Norway – NORBRAIN
Project name : -
Grant ID : P41EB015896; S10RR023043; 1S10RR023401 and 1S10RR019307
Funding program : -
Funding organization : National Institutes of Health

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 245 Sequence Number: 118723 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166