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  Mycobacterium leprae diversity and population dynamics in medieval Europe from novel ancient genomes

Pfrengle, S., Neukamm, J., Guellil, M., Keller, M., Molak, M., Avanzi, C., et al. (2021). Mycobacterium leprae diversity and population dynamics in medieval Europe from novel ancient genomes. BMC Biology, 19(1): 220. doi:10.1186/s12915-021-01120-2.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0009-79CC-A Version Permalink: https://hdl.handle.net/21.11116/0000-0009-79CD-9
Genre: Journal Article

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Additional file 1 (Supplementary material)
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Supplementary Information, Supplementary Note 1 -3, Fig. S1. -S7, Table S1-S3 + S6. - (last seen: Nov. 2021)
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Table S4. - xlsx. - (last seen: Nov. 2021)
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 Creators:
Pfrengle, Saskia, Author
Neukamm, Judith, Author
Guellil, Meriam, Author
Keller, Marcel, Author
Molak, Martyna, Author
Avanzi, Charlotte, Author
Kushniarevich, Alena, Author
Montes, Núria, Author
Neumann, Gunnar U.1, Author           
Reiter, Ella, Author
Tukhbatova, Rezeda I.1, Author           
Berezina, Nataliya Y., Author
Buzhilova, Alexandra P., Author
Korobov, Dmitry S., Author
Suppersberger Hamre, Stian, Author
Matos, Vitor M. J., Author
Ferreira, Maria T., Author
González-Garrido, Laura, Author
Wasterlain, Sofia N., Author
Lopes, Célia, Author
Santos, Ana Luisa, AuthorAntunes-Ferreira, Nathalie, AuthorDuarte, Vitória, AuthorSilva, Ana Maria, AuthorMelo, Linda, AuthorSarkic, Natasa, AuthorSaag, Lehti, AuthorTambets, Kristiina, AuthorBusso, Philippe, AuthorCole, Stewart T., AuthorAvlasovich, Alexei, AuthorRoberts, Charlotte A., AuthorSheridan, Alison, AuthorCessford, Craig, AuthorRobb, John, AuthorKrause, Johannes1, Author           Scheib, Christiana L., AuthorInskip, Sarah A., AuthorSchuenemann, Verena J., Author more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: Ancient DNA, Ancient pathogen genomics, Mycobacterium leprae, Pathogen diversity, Leprosaria,Pathogen population dynamics, Paleomicrobiology, Paleopathology
 Abstract: Hansen’s disease (leprosy), widespread in medieval Europe, is today mainly prevalent in tropical and subtropical regions with around 200,000 new cases reported annually. Despite its long history and appearance in historical records, its origins and past dissemination patterns are still widely unknown. Applying ancient DNA approaches to its major causative agent, Mycobacterium leprae, can significantly improve our understanding of the disease’s complex history. Previous studies have identified a high genetic continuity of the pathogen over the last 1500 years and the existence of at least four M. leprae lineages in some parts of Europe since the Early Medieval period.

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Language(s): eng - English
 Dates: 2021-10-05
 Publication Status: Published online
 Pages: 18
 Publishing info: -
 Table of Contents: Background
Results
- Sample information and dating
- Genome reconstruction
- Phylogenetic analysis
- Genotyping and SNP effect analysis of the new strains
- Estimation of divergence times (BEAST analysis)
Discussion
Conclusion
Methods
- Material: sample information
- Methods: sample processing
 Rev. Type: Peer
 Identifiers: DOI: 10.1186/s12915-021-01120-2
Other: Pfrengle2021
 Degree: -

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Title: BMC Biology
Source Genre: Journal
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Publ. Info: Berlin ; Heidelberg : Springer
Pages: - Volume / Issue: 19 (1) Sequence Number: 220 Start / End Page: - Identifier: ISSN: 1741-7007
CoNE: https://pure.mpg.de/cone/journals/resource/111071069889000