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  Circadian clocks guide dendritic cells into skin lymphatics

Holtkamp, S. J., Ince, L. M., Barnoud, C., Schmitt, M. T., Sinturel, F., Pilorz, V., et al. (2021). Circadian clocks guide dendritic cells into skin lymphatics. Nature Immunology, 22, 1375-1381. doi:10.1038/s41590-021-01040-x.

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Holtkamp, Stephan J., Author
Ince, Louise M., Author
Barnoud, Coline, Author
Schmitt, Madeleine T., Author
Sinturel, Flore, Author
Pilorz, Violetta, Author
Pick, Robert, Author
Jemelin, Stephane, Author
Muehlstaedt, Michael, Author
Boehncke, Wolf-Henning, Author
Weber, Jasmin, Author
Laubender, David1, Author           
Philippou-Massier, Julia, Author
Chen, Chien-Sin, Author
Holtermann, Leonie, Author
Vestweber, Dietmar, Author
Sperandio, Markus, Author
Schraml, Barbara U., Author
Halin, Cornelia, Author
Dibner, Charna, Author
Oster, Henrik, AuthorRenkawitz, Joerg, AuthorScheiermann, Christoph, Author more..
Affiliations:
1Department: Synapses-Circuits-Plasticity / Bonhoeffer, MPI of Neurobiology, Max Planck Society, ou_1113545              

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Free keywords: IMMUNE-RESPONSE; TRAFFICKING; CCL21; INFLAMMATION; EXPRESSION; MIGRATIONImmunology;
 Abstract: Scheiermann and colleagues show that circadian clocks control the infiltration of dendritic cells into skin lymphatics in mice and humans, with a peak migration to the lymph nodes during the rest phase. Migration of leukocytes from the skin to lymph nodes (LNs) via afferent lymphatic vessels (LVs) is pivotal for adaptive immune responses(1,2). Circadian rhythms have emerged as important regulators of leukocyte trafficking to LNs via the blood(3,4). Here, we demonstrate that dendritic cells (DCs) have a circadian migration pattern into LVs, which peaks during the rest phase in mice. This migration pattern is determined by rhythmic gradients in the expression of the chemokine CCL21 and of adhesion molecules in both mice and humans. Chronopharmacological targeting of the involved factors abrogates circadian migration of DCs. We identify cell-intrinsic circadian oscillations in skin lymphatic endothelial cells (LECs) and DCs that cogovern these rhythms, as their genetic disruption in either cell type ablates circadian trafficking. These observations indicate that circadian clocks control the infiltration of DCs into skin lymphatics, a process that is essential for many adaptive immune responses and relevant for vaccination and immunotherapies.

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Language(s): eng - English
 Dates: 2021-11-01
 Publication Status: Published in print
 Pages: 23
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 Table of Contents: -
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Title: Nature Immunology
  Other : Nat. Immunol.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 22 Sequence Number: - Start / End Page: 1375 - 1381 Identifier: ISSN: 1529-2908
CoNE: https://pure.mpg.de/cone/journals/resource/974392607073