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  An engram of intentionally forgotten information

Ten Oever, S., Sack, A. T., Oehrn, C. R., & Axmacher, N. (2021). An engram of intentionally forgotten information. Nature Communications, 12: 6443. doi:10.1038/s41467-021-26713-x.

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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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 Creators:
Ten Oever, Sanne1, 2, 3, Author           
Sack, Alexander T.3, 4, Author
Oehrn, Carina R.5, Author
Axmacher, Nikolai6, 7, Author
Affiliations:
1Language and Computation in Neural Systems, MPI for Psycholinguistics, Max Planck Society, ou_3217300              
2FC Donders Centre for Cognitive Neuroimaging , External Organizations, ou_55235              
3Maastricht University, Maastricht, The Netherlands, ou_persistent22              
4Maastricht University Medical Centre, Maastricht, The Netherlands, ou_persistent22              
5Philipps-University Marburg, Marburg, Germany, ou_persistent22              
6Ruhr University Bochum, Bochum, Germany, ou_persistent22              
7Beijing Normal University, Beijing, China, ou_persistent22              

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 Abstract: Successful forgetting of unwanted memories is crucial for goal-directed behavior and mental wellbeing. While memory retention strengthens memory traces, it is unclear what happens to memory traces of events that are actively forgotten. Using intracranial EEG recordings from lateral temporal cortex, we find that memory traces for actively forgotten information are partially preserved and exhibit unique neural signatures. Memory traces of successfully remembered items show stronger encoding-retrieval similarity in gamma frequency patterns. By contrast, encoding-retrieval similarity of item-specific memory traces of actively forgotten items depend on activity at alpha/beta frequencies commonly associated with functional inhibition. Additional analyses revealed selective modification of item-specific patterns of connectivity and top-down information flow from dorsolateral prefrontal cortex to lateral temporal cortex in memory traces of intentionally forgotten items. These results suggest that intentional forgetting relies more on inhibitory top-down connections than intentional remembering, resulting in inhibitory memory traces with unique neural signatures and representational formats.

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Language(s): eng - English
 Dates: 2021-11-08
 Publication Status: Published online
 Pages: -
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-021-26713-x
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 12 Sequence Number: 6443 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723