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Free keywords:
sulfoxide C-H acids; stereogenic sulfur; trifyl groups; strong acid; noncoordinating anions; Brønsted acids
Abstract:
We report the design and synthesis of a strong, chiral, enantiopure sulfoxide-based C–H acid. Single crystal X-ray analysis confirms the proposed structure and its absolute configuration. The new motif shows a high acidity and activity in Brønsted and Lewis acid catalyzed transformations. So far,only little to no enantioselectivities were achieved.