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  Enhanced antiviral function of magnesium chloride-modified Heparin on a broad spectrum of viruses

Mese, K., Bunz, O., Volkwein, W., Vemulapalli, S. P., Zhang, W. L., Schellhorn, S., et al. (2021). Enhanced antiviral function of magnesium chloride-modified Heparin on a broad spectrum of viruses. Journal of Molecular Sciences, 22(18): 10075. doi:10.3390/ijms221810075.

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 Creators:
Mese, K., Author
Bunz, O., Author
Volkwein, W., Author
Vemulapalli, S. P.1, Author              
Zhang, W. L, Author
Schellhorn, S., Author
Heenemann, K., Author
Rueckner, A., Author
Sing, A., Author
Vahlenkamp, T.W., Author
Severing, A. L., Author
Gao, J., Author
Aydin, M., Author
Jung, D., Author
Bachmann, H. S., Author
Zanker, K. S., Author
Busch, U., Author
Baiker, A., Author
Griesinger, C., Author
Griesinger, C.2, Author              
Ehrhardt, A., Author more..
Affiliations:
1Department of NMR Based Structural Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_578567              
2Department of NMR Based Structural Biology, MPI for biophysical chemistry, Max Planck Society, ou_578567              

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Free keywords: modified heparin; magnesium chloride; antiviral; HSV-1; adenovirus; SARS-CoV-2; NMR
 Abstract: Previous studies reported on the broad-spectrum antiviral function of heparin. Here we investigated the antiviral function of magnesium-modified heparin and found that modified heparin displayed a significantly enhanced antiviral function against human adenovirus (HAdV) in immortalized and primary cells. Nuclear magnetic resonance analyses revealed a conformational change of heparin when complexed with magnesium. To broadly explore this discovery, we tested the antiviral function of modified heparin against herpes simplex virus type 1 (HSV-1) and found that the replication of HSV-1 was even further decreased compared to aciclovir. Moreover, we investigated the antiviral effect against the new severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) and measured a 55-fold decreased viral load in the supernatant of infected cells associated with a 38-fold decrease in virus growth. The advantage of our modified heparin is an increased antiviral effect compared to regular heparin.

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Language(s): eng - English
 Dates: 2021-09-17
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3390/ijms221810075
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Title: Journal of Molecular Sciences
Source Genre: Journal
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Pages: 14 Volume / Issue: 22 (18) Sequence Number: 10075 Start / End Page: - Identifier: -