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  Spontaneous enhancement of magnetic resonance signals using a RASER

Korchak, S., Kaltschnee, L., Dervisoglu, R., Andreas, L. B., Griesinger, C., & Glöggler, S. (2021). Spontaneous enhancement of magnetic resonance signals using a RASER. Angewandte Chemie International Edition, 60(38), 20984-20990. doi:10.1002/ange.202108306.

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Genre: Journal Article

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 Creators:
Korchak, S.1, Author              
Kaltschnee, L.1, Author              
Dervisoglu, R.2, Author              
Andreas, L. B.2, Author              
Griesinger, C.3, Author              
Glöggler, S.1, Author              
Affiliations:
1Research Group of NMR Signal Enhancement, MPI for Biophysical Chemistry, Max Planck Society, ou_2396691              
2Research Group of Solid State NMR Spectroscopy-2, MPI for Biophysical Chemistry, Max Planck Society, ou_2396693              
3Department of NMR Based Structural Biology, MPI for biophysical chemistry, Max Planck Society, ou_578567              

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 Abstract: Nuclear magnetic resonance is usually drastically limited by its intrinsically low sensitivity: Only a few spins contribute to the overall signal. To overcome this limitation, hyperpolarization methods were developed that increase signals several times beyond the normal/thermally polarized signals. The ideal case would be a universal approach that can signal enhance the complete sample of interest in solution to increase detection sensitivity. Here, we introduce a combination of para-hydrogen enhanced magnetic resonance with the phenomenon of the RASER: Large signals of para-hydrogen enhanced molecules interact with the magnetic resonance coil in a way that the signal is spontaneously converted into an in-phase signal. These molecules directly interact with other compounds via dipolar couplings and enhance their signal. We demonstrate that this is not only possible for solvent molecules but also for an amino acid.

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Language(s): eng - English
 Dates: 2021-07-212021-09-13
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/ange.202108306
 Degree: -

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Title: Angewandte Chemie International Edition
Source Genre: Journal
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Pages: - Volume / Issue: 60 (38) Sequence Number: - Start / End Page: 20984 - 20990 Identifier: -