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  Loss of eyes in zebrafish caused by mutation of chokh/rx3

Loosli, F., Staub, W., Finger-Baier, K., Ober, E. A., Verkade, H., Wittbrodt, J., et al. (2003). Loss of eyes in zebrafish caused by mutation of chokh/rx3. EMBO Reports, 4(9), 894-899. doi:10.1038/sj.embor.embor919.

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Loosli, F., Author
Staub, W., Author
Finger-Baier, Karin1, Author           
Ober, E. A., Author
Verkade, H., Author
Wittbrodt, J., Author
Baier, Herwig1, Author           
Affiliations:
1University of California, San Francisco, U.S.A., ou_persistent22              

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Free keywords: vertebrate eye homeobox gene expression overexpression inactivation eyeless homolog retina Biochemistry & Molecular Biology Cell Biology
 Abstract: The vertebrate eye forms by specification of the retina anlage and subsequent morphogenesis of the optic vesicles, from which the neural retina differentiates. chokh (chk) mutant zebrafish lack eyes from the earliest stages in development. Marker gene analysis indicates that retinal fate is specified normally, but optic vesicle evagination and neuronal differentiation are blocked. We show that the chk gene encodes the homeodomain-containing transcription factor, Rx3. Loss of Rx3 function in another teleost, medaka, has also been shown to result in an eyeless phenotype. The medaka rx3 locus can fully rescue the zebrafish mutant phenotype. We provide evidence that the regulation of rx3 is evolutionarily conserved, whereas the downstream cascade contains significant differences in gene regulation. Thus, these mutations in orthologous genes allow us to study the evolution of vertebrate eye development at the molecular level.

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Language(s): eng - English
 Dates: 2003
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000185075400016
DOI: 10.1038/sj.embor.embor919
ISSN: 1469-221X
 Degree: -

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Title: EMBO Reports
  Other : EMBO Rep.
Source Genre: Journal
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Publ. Info: Oxford, UK : Published for EMBO by Oxford University Press
Pages: - Volume / Issue: 4 (9) Sequence Number: - Start / End Page: 894 - 899 Identifier: ISSN: 1469-221X
CoNE: https://pure.mpg.de/cone/journals/resource/110978984569661