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  Regulation of axon growth in vivo by activity-based competition

Hua, J. Y., Smear, M. C., Baier, H., & Smith, S. J. (2005). Regulation of axon growth in vivo by activity-based competition. Nature, 434(7036), 1022-1026. doi:10.1038/nature03409.

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 Creators:
Hua, J. Y., Author
Smear, M. C., Author
Baier, Herwig1, Author           
Smith, S. J., Author
Affiliations:
1University of California, San Francisco, U.S.A., ou_persistent22              

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Free keywords: visual-cortex synaptic competition ocular dominance branch dynamics neural activity zebrafish system reveals arbors brain Science & Technology - Other Topics
 Abstract: The formation of functional neural networks requires precise regulation of the growth and branching of the terminal arbors of axons, processes known to be influenced by early network electrical activity(1-3). Here we show that a rule of activity-based competition between neighbouring axons appears to govern the growth and branching of retinal ganglion cell (RGC) axon arbors in the developing optic tectum of zebrafish. Mosaic expression of an exogenous potassium channel or a dominant-negative SNARE protein was used to suppress electrical or neurosecretory activity in subsets of RGC axons. Imaging in vivo showed that these forms of activity suppression strongly inhibit both net growth and the formation of new branches by individually transfected RGC axon arbors. The inhibition is relieved when the activity of nearby 'competing' RGC axons is also suppressed. These results therefore identify a new form of activity-based competition rule that might be a key regulator of axon growth and branch initiation.

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Language(s): eng - English
 Dates: 2005
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000228524600039
DOI: 10.1038/nature03409
ISSN: 0028-0836
 Degree: -

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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Affiliations:
Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 434 (7036) Sequence Number: - Start / End Page: 1022 - 1026 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238