English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Critical Care Workers Have Lower Seroprevalence of SARS-CoV-2 IgG Compared with Non-patient Facing Staff in First Wave of COVID19

Baxendale, H. E., Wells, D., Gronlund, J., Nadesalingham, A., Paloniemi, M., Carnell, G., et al. (2021). Critical Care Workers Have Lower Seroprevalence of SARS-CoV-2 IgG Compared with Non-patient Facing Staff in First Wave of COVID19. Journal of Critical Care Medicine, 7(3), 199-210. doi:10.2478/jccm-2021-0018.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Baxendale, Helen E., Author
Wells, David, Author
Gronlund, Jessica, Author
Nadesalingham, Angalee, Author
Paloniemi, Mina, Author
Carnell, George, Author
Tonks, Paul, Author
Ceron-Gutierrez, Lourdes, Author
Ebrahimi, Soraya, Author
Sayer, Ashleigh, Author
Briggs, John A. G.1, Author              
Ziong, Xiaoli, Author
Nathan, James A., Author
Grice, Guinevere, Author
James, Leo C., Author
Luptak, Jakub, Author
Pai, Sumita, Author
Heeney, Jonathan L., Author
Lear, Sara, Author
Doffinger, Rainer, Author
Affiliations:
1MRC Laboratory of Molecular Biology, External Organizations, ou_3346673              

Content

show
hide
Free keywords: General & Internal Medicine; COVID-19; SARS-CoV-2; health care workers; critical care; seroprevalence;
 Abstract: Introduction: In early 2020, at first surge of the coronavirus disease 2019 (COVID-19) pandemic, many health care workers (HCW) were re-deployed to critical care environments to support intensive care teams looking after patients with severe COVID-19. There was considerable anxiety of increased risk of COVID-19 for these staff. To determine whether critical care HCW were at increased risk of hospital acquired infection, we explored the relationship between workplace, patient facing role and evidence of immune exposure to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within a quaternary hospital providing a regional critical care response. Routine viral surveillance was not available at this time. Methods: We screened over 500 HCW (25% of the total workforce) for history of clinical symptoms of possible COVID19, assigning a symptom severity score, and quantified SARS-CoV-2 serum antibodies as evidence of immune exposure to the virus. Results: Whilst 45% of the cohort reported symptoms that they consider may have represented COVID-19, 14% had evidence of immune exposure. Staffs in patient facing critical care roles were least likely to be seropositive (9%) and staff working in non-patient facing roles most likely to be seropositive (22%). Anosmia and fever were the most discriminating symptoms for seropositive status. Older males presented with more severe symptoms. Of the 12 staff screened positive by nasal swab (10 symptomatic), 3 showed no evidence of seroconversion in convalescence. Conclusions: Patient facing staff working in critical care do not appear to be at increased risk of hospital acquired infection however the risk of nosocomial infection from non-patient facing staff may be more significant than previous recognised. Most symptoms ascribed to possible COVID-19 were found to have no evidence of immune exposure however seroprevalence may underrepresent infection frequency. Older male staff were at the greatest risk of more severe symptoms.

Details

show
hide
Language(s): eng - English
 Dates: 2021
 Publication Status: Published in print
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000683331000006
DOI: 10.2478/jccm-2021-0018
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Critical Care Medicine
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: BOGUMILA ZUGA 32A, WARSAW, MAZOVIA, POLAND : SCIENDO
Pages: - Volume / Issue: 7 (3) Sequence Number: - Start / End Page: 199 - 210 Identifier: ISSN: 2393-1809