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  Mathematical learning deficits originate in early childhood from atypical development of a frontoparietal brain network

Kuhl, U., Sobotta, S., Legascreen Consortium, & Skeide, M. A. (2021). Mathematical learning deficits originate in early childhood from atypical development of a frontoparietal brain network. PLoS Biology, 19(9): e3001407. doi:10.1371/journal.pbio.3001407.

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 Creators:
Kuhl, Ulrike1, 2, Author              
Sobotta, Sarah3, Author
Legascreen Consortium, Author              
Skeide, Michael A.3, Author              
Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
2Machine Learning Group, Faculty of Technology, University of Bielefeld, Germany, ou_persistent22              
3Max Planck Research Group Learning in Early Childhood, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3340643              

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 Abstract: Mathematical learning deficits are defined as a neurodevelopmental disorder (dyscalculia) in the International Classification of Diseases. It is not known, however, how such deficits emerge in the course of early brain development. Here, we conducted functional and structural magnetic resonance imaging (MRI) experiments in 3- to 6-year-old children without formal mathematical learning experience. We followed this sample until the age of 7 to 9 years, identified individuals who developed deficits, and matched them to a typically developing control group using comprehensive behavioral assessments. Multivariate pattern classification distinguished future cases from controls with up to 87% accuracy based on the regional functional activity of the right posterior parietal cortex (PPC), the network-level functional activity of the right dorsolateral prefrontal cortex (DLPFC), and the effective functional and structural connectivity of these regions. Our results indicate that mathematical learning deficits originate from atypical development of a frontoparietal network that is already detectable in early childhood.

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Language(s): eng - English
 Dates: 2021-02-152021-09-062021-09-30
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1371/journal.pbio.3001407
Other: eCollection 2021
PMID: 34591838
PMC: PMC8509954
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Project name : -
Grant ID : M.FE.A.NEPF0001
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Funding organization : Max Planck Society and the Fraunhofer Society

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Title: PLoS Biology
  Other : PLoS Biol.
Source Genre: Journal
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Publ. Info: San Francisco, California, US : Public Library of Science
Pages: - Volume / Issue: 19 (9) Sequence Number: e3001407 Start / End Page: - Identifier: ISSN: 1544-9173
CoNE: https://pure.mpg.de/cone/journals/resource/111056649444170