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  Vesicular glutamate transport at a central synapse limits the acuity of visual perception in zebrafish

Smear, M. C., Tao, H. Z. W., Staub, W., Orger, M. B., Gosse, N. J., Liu, Y., et al. (2007). Vesicular glutamate transport at a central synapse limits the acuity of visual perception in zebrafish. Neuron, 53(1), 65-77. doi:10.1016/j.neuron.2006.12.013.

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 Creators:
Smear, M. C., Author
Tao, H. Z. W., Author
Staub, W., Author
Orger, M. B., Author
Gosse, N. J., Author
Liu, Yan, Author
Takahashi, Koji, Author
Poo, M. M., Author
Baier, Herwig1, Author           
Affiliations:
1University of California, San Francisco, U.S.A., ou_persistent22              

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Free keywords: retinal ganglion-cells larval zebrafish retinotectal projection in-vivo phosphate transporter postnatal-development contrast sensitivity system development spatial vision prey capture Neurosciences & Neurology
 Abstract: The neural circuitry that constrains visual acuity in the CNS has not been experimentally identified. We show here that zebrafish blumenkohl (blu) mutants are impaired in resolving rapid movements and fine spatial detail. The blu gene encodes a vesicular glutamate transporter expressed by retinal ganglion cells. Mutant retinotectal synapses release less glutamate, per vesicle and per terminal, and fatigue more quickly than wild-type in response to high-frequency stimulation. In addition, mutant axons arborize more extensively, thus increasing the number of synaptic terminals and effectively normalizing the combined input to postsynaptic cells in the tectum. This presumably homeostatic response results in larger receptive fields of tectal cells and a degradation of the retinotopic map. As predicted, mutants have a selective deficit in the capture of small prey objects, a behavior dependent on the tecturn. Our studies successfully link the disruption of a synaptic protein to complex changes in neural circuitry and behavior.

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Language(s): eng - English
 Dates: 2007
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000245126500009
DOI: 10.1016/j.neuron.2006.12.013
ISSN: 0896-6273
 Degree: -

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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 53 (1) Sequence Number: - Start / End Page: 65 - 77 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565