English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Chromatin-state barriers enforce an irreversible mammalian cell fate decision

Blanco, M. A., Sykes, D. B., Gu, L., Wu, M., Petroni, R., Karnik, R., et al. (2021). Chromatin-state barriers enforce an irreversible mammalian cell fate decision. Cell Reports, 37(6): 109967. doi:10.1016/j.celrep.2021.109967.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
Blanco_2021.pdf (Publisher version), 4MB
Name:
Blanco_2021.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
© Blanco et al, 2021

Locators

show

Creators

show
hide
 Creators:
Blanco, M. Andres, Author
Sykes, David B., Author
Gu, Lei, Author
Wu, Mengjun, Author
Petroni, Ricardo, Author
Karnik, Rahul, Author
Wawer, Mathias, Author
Rico, Joshua, Author
Li, Haitao, Author
Jacobus, William D., Author
Jambhekar, Ashwini, Author
Cheloufi, Sihem, Author
Meissner, Alexander1, Author              
Hochedlinger, Konrad, Author
Scadden, David T., Author
Shi, Yang, Author
Affiliations:
1Dept. of Genome Regulation (Head: Alexander Meissner), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2379694              

Content

show
hide
Free keywords: -
 Abstract: Stem and progenitor cells have the capacity to balance self-renewal and differentiation. Hematopoietic myeloid progenitors replenish more than 25 billion terminally differentiated neutrophils every day under homeostatic conditions and can increase this output in response to stress or infection. At what point along the spectrum of maturation do progenitors lose capacity for self-renewal and become irreversibly committed to differentiation? Using a system of conditional myeloid development that can be toggled between self-renewal and differentiation, we interrogate determinants of this "point of no return"in differentiation commitment. Irreversible commitment is due primarily to loss of open regulatory site access and disruption of a positive feedback transcription factor activation loop. Restoration of the transcription factor feedback loop extends the window of cell plasticity and alters the point of no return. These findings demonstrate how the chromatin state enforces and

Details

show
hide
Language(s): eng - English
 Dates: 2021-11-09
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cell Reports
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Maryland Heights, MO : Cell Press
Pages: - Volume / Issue: 37 (6) Sequence Number: 109967 Start / End Page: - Identifier: ISSN: 2211-1247
CoNE: https://pure.mpg.de/cone/journals/resource/2211-1247