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  Right ventral stream damage underlies both poststroke aprosodia and amusia

Sihvonen, A. J., Sammler, D., Ripollés, P., Leo, V., Rodríguez-Fornells, A., Soinila, S., et al. (2022). Right ventral stream damage underlies both poststroke aprosodia and amusia. European Journal of Neurology, 29(3), 873-882. doi:10.1111/ene.15148.

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 Creators:
Sihvonen, Aleksi J.1, 2, Author
Sammler, Daniela3, Author              
Ripollés, Pablo4, Author
Leo, Vera1, Author
Rodríguez-Fornells, Antoni5, 6, 7, Author
Soinila, Seppo8, Author
Särkämö, Teppo1, Author
Affiliations:
1Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland, ou_persistent22              
2Centre for Clinical Research, University of Queensland, Brisbane, Australia, ou_persistent22              
3Research Group Neurocognition of Music and Language, Max Planck Institute for Empirical Aesthetics, Frankfurt, Germany, ou_persistent22              
4Department of Psychology, New York University, NY, USA, ou_persistent22              
5Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute (IDIBELL), Llobregat, Spain, ou_persistent22              
6Department of Cognition, Development and Educational Psychology, University of Barcelona, Spain, ou_persistent22              
7Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Spain, ou_persistent22              
8Neurocenter, University of Turku, Finland, ou_persistent22              

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Free keywords: Amusia; Aprosodia; Lesion–symptom mapping; Stroke; Tractography
 Abstract: Background and purpose: This study was undertaken to determine and compare lesion patterns and structural dysconnectivity underlying poststroke aprosodia and amusia, using a data-driven multimodal neuroimaging approach. Methods: Thirty-nine patients with right or left hemisphere stroke were enrolled in a cohort study and tested for linguistic and affective prosody perception and musical pitch and rhythm perception at subacute and 3-month poststroke stages. Participants listened to words spoken with different prosodic stress that changed their meaning, and to words spoken with six different emotions, and chose which meaning or emotion was expressed. In the music tasks, participants judged pairs of short melodies as the same or different in terms of pitch or rhythm. Structural magnetic resonance imaging data were acquired at both stages, and machine learning-based lesion-symptom mapping and deterministic tractography were used to identify lesion patterns and damaged white matter pathways giving rise to aprosodia and amusia. Results: Both aprosodia and amusia were behaviorally strongly correlated and associated with similar lesion patterns in right frontoinsular and striatal areas. In multiple regression models, reduced fractional anisotropy and lower tract volume of the right inferior fronto-occipital fasciculus were the strongest predictors for both disorders, over time. Conclusions: These results highlight a common origin of aprosodia and amusia, both arising from damage and disconnection of the right ventral auditory stream integrating rhythmic-melodic acoustic information in prosody and music. Comorbidity of these disabilities may worsen the prognosis and affect rehabilitation success.

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Language(s): eng - English
 Dates: 2021-10-182022-02-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1111/ene.15148
Other: epub 2022
PMID: 34661326
 Degree: -

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Title: European Journal of Neurology
  Other : Eur. J. Neurol.
Source Genre: Journal
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Publ. Info: Oxford : Rapid Communications
Pages: - Volume / Issue: 29 (3) Sequence Number: - Start / End Page: 873 - 882 Identifier: ISSN: 1351-5101
CoNE: https://pure.mpg.de/cone/journals/resource/954925617087