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  Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference

Castro Alvarez, J. J., Revel, M., Carrasco Sala, J., Cléard, F., Pauli, D., Hilgers, V., et al. (2021). Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference. PLoS Genetics, 17(11): e1009843. doi:10.1371/journal.pgen.1009843.

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Castro Alvarez et al. 2021.pdf (Publisher version), 3MB
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Castro Alvarez et al.
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 Creators:
Castro Alvarez, Javier J.1, Author
Revel, Maxime1, Author
Carrasco Sala, Judit2, Author              
Cléard, Fabienne1, Author
Pauli, Daniel1, Author
Hilgers, Valérie2, Author              
Karch, François1, Author
Maeda, Robert K.1, Author
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1External Organizations, ou_persistent22              
2Department Independent Research Groups, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243640              

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 Abstract: Intergenic transcription is a common feature of eukaryotic genomes and performs important and diverse cellular functions. Here, we investigate the iab-8 ncRNA from the Drosophila Bithorax Complex and show that this RNA is able to repress the transcription of genes located at its 3’ end by a sequence-independent, transcriptional interference mechanism. Although this RNA is expressed in the early epidermis and CNS, we find that its repressive activity is limited to the CNS, where, in wild-type embryos, it acts on the Hox gene, abd-A, located immediately downstream of it. The CNS specificity is achieved through a 3’ extension of the transcript, mediated by the neuronal-specific, RNA-binding protein, ELAV. Loss of ELAV activity eliminates the 3’ extension and results in the ectopic activation of abd-A. Thus, a tissue-specific change in the length of a ncRNA is used to generate a precise pattern of gene expression in a higher eukaryote.

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Language(s): eng - English
 Dates: 2021-11-15
 Publication Status: Published online
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 Rev. Type: Peer
 Identifiers: DOI: 10.1371/journal.pgen.1009843
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Title: PLoS Genetics
  Other : PLoS Genet.
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 17 (11) Sequence Number: e1009843 Start / End Page: - Identifier: ISSN: 1553-7390
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000017180