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  Clonally related forebrain interneurons disperse broadly across both functional areas and structural boundaries

Mayer, C., Jaglin, X. H., Cobbs, L. V., Bandler, R. C., Streicher, C., Cepko, C. L., et al. (2015). Clonally related forebrain interneurons disperse broadly across both functional areas and structural boundaries. Neuron, 87(5), 989-998. doi:10.1016/j.neuron.2015.07.011.

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 Creators:
Mayer, Christian1, Author           
Jaglin, X. H., Author
Cobbs, L. V., Author
Bandler, Rachel C.1, Author           
Streicher, C., Author
Cepko, C. L., Author
Hippenmeyer, S., Author
Fishell, Gord, Author
Affiliations:
1NYU Langone Medical Center, New York, U. S. A. , ou_persistent22              

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Free keywords: cortical interneurons in-vivo gabaergic interneurons striatal interneurons ganglionic eminence retroviral vectors lineage analysis cells migration mouse Neurosciences & Neurology
 Abstract: The medial ganglionic eminence (MGE) gives rise to the majority of mouse forebrain interneurons. Here, we examine the lineage relationship among MGE-derived interneurons using a replication-defective retroviral library containing a highly diverse set of DNA barcodes. Recovering the barcodes from the mature progeny of infected progenitor cells enabled us to unambiguously determine their respective lineal relationship. We found that clonal dispersion occurs across large areas of the brain and is not restricted by anatomical divisions. As such, sibling interneurons can populate the cortex, hippocampus striatum, and globus pallidus. The majority of interneurons appeared to be generated from asymmetric divisions of MGE progenitor cells, followed by symmetric divisions within the subventricular zone. Altogether, our findings uncover that lineage relationships do not appear to determine interneuron allocation to particular regions. As such, it is likely that clonally related interneurons have considerable flexibility as to the particular forebrain circuits to which they can contribute.

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Language(s): eng - English
 Dates: 2015
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000361146300009
DOI: 10.1016/j.neuron.2015.07.011
 Degree: -

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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 87 (5) Sequence Number: - Start / End Page: 989 - 998 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565