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  Jujube metabolome selection determined the edible properties acquired during domestication

Zhang, Z., Shi, Q., Wang, B., Ma, A., Wang, Y., Xue, Q., et al. (2021). Jujube metabolome selection determined the edible properties acquired during domestication. The Plant Journal. doi:10.1111/tpj.15617.

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Genre: Journal Article
Alternative Title : The Plant Journal

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 Creators:
Zhang, Zhong1, Author
Shi, Qianqian1, Author
Wang, Bin1, Author
Ma, Aimin1, Author
Wang, Yongkang1, Author
Xue, Qingtun1, Author
Shen, Bingqi1, Author
Hamaila, Halina1, Author
Tang, Tang1, Author
Qi, Xiaoquan1, Author
Fernie, A. R.2, Author              
Luo, Jie1, Author
Li, Xingang1, Author
Affiliations:
1external, ou_persistent22              
2Central Metabolism, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753339              

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Free keywords: domestication, metabolome, genome-wide association study, specialized metabolites, triterpene, alkaloid, fruit tree, jujube
 Abstract: SUMMARY Plants supply both food and medicinal compounds, which are ascribed to diverse metabolites produced by plants. However, studies on domestication-driven changes in the metabolome and genetic basis of bioactive molecules in perennial fruit trees are generally lacking. Here, we conducted multidimensional analyses revealing a singular domestication event involving the genomic and metabolomic selection of jujube trees (Ziziphus jujuba Mill.). The genomic selection for domesticated genes was highly enriched in metabolic pathways, including carbohydrates and specialized metabolism. Domesticated metabolome profiling indicated that 187 metabolites exhibited significant divergence due to directional selection. Malic acid was directly selected during domestication, and the simultaneous selection of specialized metabolites, including triterpenes, consequently lead to edible properties. Cyclopeptide alkaloids (CPA) were specifically targeted for the divergence between dry and fresh cultivars. We identified 1,080 significantly associated loci for 986 metabolites. Among them, 15 triterpenes were directly selected at six major loci, allowing the identification of a homologous cluster containing seven 2,3-oxidosqualene cyclases (OSCs). An OSC gene was found to contribute to the reduction in the content of triterpenes during domestication. The complete pathway for synthesizing ursolic acid was dissected by integration of the metabolome and transcriptome. Additionally, an N-methyltransferase involved in the biosynthesis of CPA and responsible for inter-cultivar content variation was identified. This study promotes our understanding of the selection process of the global metabolome since fruit tree domestication and facilitates the genetic manipulation of specialized metabolites to enhance their edible traits.

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Language(s): eng - English
 Dates: 2021-12-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1111/tpj.15617
 Degree: -

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Title: The Plant Journal
  Other : Plant J.
Source Genre: Journal
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Publ. Info: Oxford : Blackwell Science
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0960-7412
CoNE: https://pure.mpg.de/cone/journals/resource/954925579095_1

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Title: The Plant Journal
Source Genre: Journal
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Publ. Info: John Wiley & Sons, Ltd
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISBN: 0960-7412