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Free keywords:
glycolysis neurodegeneration OXPHOS synaptic transmission
Abstract:
Mitochondria are the main suppliers of neuronal adenosine triphosphate
and play a critical role in brain energy metabolism. Mitochondria also
serve as Ca2+ sinks and anabolic factories and are therefore essential
for neuronal function and survival. Dysregulation of neuronal
bioenergetics is increasingly implicated in neurodegenerative disorders,
particularly Parkinson's disease. This review describes the role of
mitochondria in energy metabolism under resting conditions and during
synaptic transmission, and presents evidence for the contribution of
neuronal mitochondrial dysfunction to Parkinson's disease.
