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  The insula cortex contacts distinct output streams of the central amygdala

Ponserre, M., Peters, C., Fermani, F., Conzelmann, K.-K., & Klein, R. (2020). The insula cortex contacts distinct output streams of the central amygdala. The Journal of Neuroscience, 40(46), 8870-8882. doi:10.1523/JNEUROSCI.0567-20.2020.

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 Creators:
Ponserre, Marion1, Author           
Peters, Christian1, Author           
Fermani, Federica1, Author           
Conzelmann, Karl-Klaus, Author
Klein, Rüdiger1, Author           
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1Department: Molecules-Signaling-Development / Klein, MPI of Neurobiology, Max Planck Society, ou_1113546              

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Free keywords: central amygdalainput-output relationshipinsula cortexlateral hypothalamusmonosynaptic tracingoptogenetics
 Abstract: The emergence of genetic tools has provided new means of mapping functionality in central amygdala (CeA) neuron populations based on their molecular profiles, response properties, and importantly, connectivity patterns. While abundant evidence indicates that neuronal signals arrive in the CeA eliciting both aversive and appetitive behaviors, our understanding of the anatomy of the underlying long-range CeA network remains fragmentary. In this study, we combine viral tracings, electrophysiological, and optogenetic approaches to establish in male mice, a wiring chart between the insula cortex (IC), a major sensory input region of the lateral and capsular part of the CeA (CeL/C), and four principal output streams of this nucleus. We found that retrogradely labeled output neurons occupy discrete and likely strategic locations in the CeL/C, and that they are disproportionally controlled by the IC. We identified a direct line of connection between the IC and the lateral hypothalamus (LH), which engages numerous LH-projecting CeL/C cells whose activity can be strongly upregulated on firing of IC neurons. In comparison, CeL/C neurons projecting to the bed nucleus of the stria terminalis (BNST) are also frequently contacted by incoming IC axons, but the strength of this connection is weak. Our results provide a link between long-range inputs and outputs of the CeA and pave the way to a better understanding of how internal, external, and experience dependent information may impinge on action selection by the CeA.

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 Dates: 2020-11-11
 Publication Status: Published in print
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Project name : SPP1665; SFB870
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Funding organization : Deutsche Forschungsgemeinschaft (DFG)

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Title: The Journal of Neuroscience
  Other : The Journal of Neuroscience: the Official Journal of the Society for Neuroscience
  Abbreviation : J. Neurosci.
Source Genre: Journal
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Publ. Info: Washington, DC : Society of Neuroscience
Pages: - Volume / Issue: 40 (46) Sequence Number: - Start / End Page: 8870 - 8882 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1