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  Structural connectivity gradients of the temporal lobe serve as multiscale axes of brain organization and cortical evolution

de Wael, R. V., Royer, J., Tavakol, S., Wang, Y., Paquola, C., Benkarim, O., et al. (2021). Structural connectivity gradients of the temporal lobe serve as multiscale axes of brain organization and cortical evolution. Cerebral Cortex, 31(11), 5151-5164. doi:10.1093/cercor/bhab149.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0009-99C8-9 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-57C3-5
Genre: Journal Article

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 Creators:
de Wael, Reinder Vos1, Author
Royer, Jessica1, Author
Tavakol, Shahin1, Author
Wang, Yezhou1, Author
Paquola, Casey1, Author
Benkarim, Oualid1, Author
Eichert, Nicole2, Author
Larivière, Sara1, Author
Xu, Ting3, Author
Misic, Bratislav1, Author
Smallwood, Jonathan4, Author
Valk, Sofie L.5, Author           
Bernhardt, Boris C1, Author
Affiliations:
1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22              
2Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
3Center for the Developing Brain, Child Mind Institute, New York, NY, USA, ou_persistent22              
4Queen’s University, Kingston, ON, Canada, ou_persistent22              
5Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              

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Free keywords: MRI; Connectome; Gradients; Multimodal; Neuroimaging
 Abstract: The temporal lobe is implicated in higher cognitive processes and is one of the regions that underwent substantial reorganization during primate evolution. Its functions are instantiated, in part, by the complex layout of its structural connections. Here, we identified low-dimensional representations of structural connectivity variations in human temporal cortex and explored their microstructural underpinnings and associations to macroscale function. We identified three eigenmodes which described gradients in structural connectivity. These gradients reflected inter-regional variations in cortical microstructure derived from quantitative magnetic resonance imaging and postmortem histology. Gradient-informed models accurately predicted macroscale measures of temporal lobe function. Furthermore, the identified gradients aligned closely with established measures of functional reconfiguration and areal expansion between macaques and humans, highlighting their potential role in shaping temporal lobe function throughout primate evolution. Findings were replicated in several datasets. Our results provide robust evidence for three axes of structural connectivity in human temporal cortex with consistent microstructural underpinnings and contributions to large-scale brain network function.

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Language(s): eng - English
 Dates: 2021-06-192021-11
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/cercor/bhab149
PMID: 34148082
PMC: PMC8491677
 Degree: -

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Project name : -
Grant ID : ERC646927
Funding program : -
Funding organization : European Research Council (ERC)
Project name : -
Grant ID : 1304413
Funding program : -
Funding organization : National Science and Engineering Research Council of Canada (NSERC)
Project name : -
Grant ID : FDN-154298; PJT-174995
Funding program : -
Funding organization : Canadian Institutes of Health Research (CIHR)
Project name : -
Grant ID : NI17–039
Funding program : -
Funding organization : SickKids Foundation
Project name : -
Grant ID : -
Funding program : -
Funding organization : Savoy Foundation for Epilepsy
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Grant ID : -
Funding program : -
Funding organization : Richard and Ann Sievers award
Project name : -
Grant ID : -
Funding program : -
Funding organization : Canadian Open Neuroscience Platform (CONP)
Project name : -
Grant ID : -
Funding program : -
Funding organization : McGill University’s Faculty of Medicine
Project name : -
Grant ID : -
Funding program : -
Funding organization : Fonds de la Recherche du Quebec—Santé (FRQ-S)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Healthy Brains for Healthy Lives (HBHL)

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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 31 (11) Sequence Number: - Start / End Page: 5151 - 5164 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440