Structural connectivity gradients of the temporal lobe serve as multiscale axes 
of brain organization and cortical evolution

de Wael, Reinder Vos; Royer, Jessica; Tavakol, Shahin; Wang, Yezhou; Paquola, Casey; Benkarim, Oualid; Eichert, Nicole; Larivière, Sara; Xu, Ting; Misic, Bratislav; Smallwood, Jonathan; Valk, Sofie L.; Bernhardt, Boris C

doi:10.1093/cercor/bhab149

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Structural connectivity gradients of the temporal lobe serve as multiscale axes of brain organization and cortical evolution

de Wael, R. V., Royer, J., Tavakol, S., Wang, Y., Paquola, C., Benkarim, O., et al. (2021). Structural connectivity gradients of the temporal lobe serve as multiscale axes of brain organization and cortical evolution. Cerebral Cortex, 31(11), 5151-5164. doi:10.1093/cercor/bhab149.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0009-99C8-9 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000D-57C3-5

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Urheber:
de Wael, Reinder Vos¹, Autor
Royer, Jessica¹, Autor
Tavakol, Shahin¹, Autor
Wang, Yezhou¹, Autor
Paquola, Casey¹, Autor
Benkarim, Oualid¹, Autor
Eichert, Nicole², Autor
Larivière, Sara¹, Autor
Xu, Ting³, Autor
Misic, Bratislav¹, Autor
Smallwood, Jonathan⁴, Autor
Valk, Sofie L.⁵, Autor
Bernhardt, Boris C¹, Autor

Affiliations:
1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22
2Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22
3Center for the Developing Brain, Child Mind Institute, New York, NY, USA, ou_persistent22
4Queen’s University, Kingston, ON, Canada, ou_persistent22
5Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264

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Schlagwörter: MRI; Connectome; Gradients; Multimodal; Neuroimaging

Zusammenfassung: The temporal lobe is implicated in higher cognitive processes and is one of the regions that underwent substantial reorganization during primate evolution. Its functions are instantiated, in part, by the complex layout of its structural connections. Here, we identified low-dimensional representations of structural connectivity variations in human temporal cortex and explored their microstructural underpinnings and associations to macroscale function. We identified three eigenmodes which described gradients in structural connectivity. These gradients reflected inter-regional variations in cortical microstructure derived from quantitative magnetic resonance imaging and postmortem histology. Gradient-informed models accurately predicted macroscale measures of temporal lobe function. Furthermore, the identified gradients aligned closely with established measures of functional reconfiguration and areal expansion between macaques and humans, highlighting their potential role in shaping temporal lobe function throughout primate evolution. Findings were replicated in several datasets. Our results provide robust evidence for three axes of structural connectivity in human temporal cortex with consistent microstructural underpinnings and contributions to large-scale brain network function.

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Sprache(n): eng - English

Datum: Online veröffentlicht: 2021-06-19Erschienen: 2021-11

Publikationsstatus: Erschienen

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Identifikatoren: DOI: 10.1093/cercor/bhab149
PMID: 34148082
PMC: PMC8491677

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Grant ID : ERC646927

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Förderorganisation : European Research Council (ERC)

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Grant ID : 1304413

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Förderorganisation : National Science and Engineering Research Council of Canada (NSERC)

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Grant ID : FDN-154298; PJT-174995

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Förderorganisation : Canadian Institutes of Health Research (CIHR)

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Grant ID : NI17–039

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Förderorganisation : SickKids Foundation

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Förderorganisation : Savoy Foundation for Epilepsy

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Förderorganisation : Richard and Ann Sievers award

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Förderorganisation : Canadian Open Neuroscience Platform (CONP)

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Förderorganisation : McGill University’s Faculty of Medicine

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Förderorganisation : Fonds de la Recherche du Quebec—Santé (FRQ-S)

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Förderorganisation : Healthy Brains for Healthy Lives (HBHL)

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Titel: Cerebral Cortex

Genre der Quelle: Zeitschrift

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Ort, Verlag, Ausgabe: New York, NY : Oxford University Press

Seiten: - Band / Heft: 31 (11) Artikelnummer: - Start- / Endseite: 5151 - 5164 Identifikator: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440

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