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  The flexibility of oligosaccharides unveiled through residual dipolar coupling analysis

Poveda, A., Fittolani, G., Seeberger, P. H., Delbianco, M., & Jiménez-Barbero, J. (2021). The flexibility of oligosaccharides unveiled through residual dipolar coupling analysis. Frontiers in Molecular Biosciences, 8 (1051): 784318. doi:10.3389/fmolb.2021.784318.

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 Creators:
Poveda, Ana, Author
Fittolani, Giulio1, Author              
Seeberger, Peter H.2, Author              
Delbianco, Martina1, Author              
Jiménez-Barbero, Jesús, Author
Affiliations:
1Martina Delbianco, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2559692              
2Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              

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Free keywords: Glycans, NMR, RDC, 13C-labeling, automated glycan assembly (AGA)
 Abstract: The intrinsic flexibility of glycans complicates the study of their structures and dynamics, which are often important for their biological function. NMR has provided insights into the conformational, dynamic and recognition features of glycans, but suffers from severe chemical shift degeneracy. We employed labelled glycans to explore the conformational behaviour of a β(1-6)-Glc hexasaccharide model through residual dipolar couplings (RDCs). RDC delivered information on the relative orientation of specific residues along the glycan chain and provided experimental clues for the existence of certain geometries. The use of two different aligning media demonstrated the adaptability of flexible oligosaccharide structures to different environments.

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Language(s): eng - English
 Dates: 2021-11-102021
 Publication Status: Published in print
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 Identifiers: DOI: 10.3389/fmolb.2021.784318
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Title: Frontiers in Molecular Biosciences
Source Genre: Journal
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Publ. Info: Schweiz : Frontiers Media
Pages: - Volume / Issue: 8 (1051) Sequence Number: 784318 Start / End Page: - Identifier: ISSN: 2296-889X