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  Interplay of trans- and cis-interactions of glycolipids in membrane adhesion

Kav, B., Demé, B., Gege, C., Tanaka, M., Schneck, E., & Weikl, T. R. (2021). Interplay of trans- and cis-interactions of glycolipids in membrane adhesion. Frontiers in Molecular Biosciences, 8 (1047): 754654. doi:10.3389/fmolb.2021.754654.

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 Creators:
Kav, Batuhan1, Author              
Demé, Bruno, Author
Gege, Christian, Author
Tanaka, Motomu, Author
Schneck, Emanuel2, Author              
Weikl, Thomas R.1, Author              
Affiliations:
1Thomas Weikl, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863330              
2Emanuel Schneck, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2074300              

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Free keywords: Glycolipids, Carbohydrate-carbohydrate interactions, LewisX carbohydrate, Membrane adhesion, Membrane shape fluctuations, Molecular dynamics simulations (MD), neutron scattering
 Abstract: Glycolipids mediate stable membrane adhesion of potential biological relevance. In this article, we investigate the <i>trans</i>- and <i>cis</i>-interactions of glycolipids in molecular dynamics simulations and relate these interactions to the glycolipid-induced average separations of membranes obtained from neutron scattering experiments. We find that the <i>cis</i>-interactions between glycolipids in the same membrane leaflet tend to strengthen the <i>trans</i>-interactions between glycolipids in apposing leaflets. The <i>trans</i>-interactions of the glycolipids in our simulations require local membrane separations that are significantly smaller than the average membrane separations in the neutron scattering experiments, which indicates an important role of membrane shape fluctuations in glycolipid <i>trans</i>-binding. Simulations at the experimentally measured average membrane separations provide a molecular picture of the interplay between glycolipid attraction and steric repulsion of the fluctuating membranes probed in the experiments.

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Language(s): eng - English
 Dates: 2021-11-192021
 Publication Status: Published in print
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.3389/fmolb.2021.754654
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Title: Frontiers in Molecular Biosciences
Source Genre: Journal
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Publ. Info: Schweiz : Frontiers Media
Pages: - Volume / Issue: 8 (1047) Sequence Number: 754654 Start / End Page: - Identifier: Other: 2296-889X