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  Diagnostic Yield of Transbronchial Lung Cryobiopsy Compared to Transbronchial Forceps Biopsy in Patients with Sarcoidosis in a Prospective, Randomized, Multicentre Cross-Over Trial

Häntschel, M., Eberhardt, R., Petermann, C., Gesierich, W., Darwiche, K., Hagmeyer, L., et al. (2012). Diagnostic Yield of Transbronchial Lung Cryobiopsy Compared to Transbronchial Forceps Biopsy in Patients with Sarcoidosis in a Prospective, Randomized, Multicentre Cross-Over Trial. Journal of Clinical Medicine, 10(23): 5686. doi:10.3390/jcm10235686.

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https://www.mdpi.com/2077-0383/10/23/5686/pdf (Publisher version)
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Häntschel, M, Author
Eberhardt, R, Author
Petermann, C, Author
Gesierich, W, Author
Darwiche, K, Author
Hagmeyer, L, Author
Colby, TV, Author
Fend, F, Author
Theegarten, D, Author
Wintzer, H-O, Author
Kreuter, M, Author
Spengler, W, Author
Behrens-Zemek, AF, Author
Lewis, RA, Author
Evrard, HC1, 2, Author              
Ehab, A, Author
Böckeler, M, Author
Hetzel, J, Author
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Background: Transbronchial lung forceps biopsy (TBLF) is of limited value for the diagnosis of interstitial lung disease (ILD). However, in cases with predominantly peribronchial pathology, such as sarcoidosis, TBLF is considered to be diagnostic in most cases. The present study examines whether transbronchial lung cryobiopsy (TBLC) is superior to TBLF in terms of diagnostic yield in cases of sarcoidosis. Methods: In this post hoc analysis of a prospective, randomized, controlled, multicentre study, 359 patients with ILD requiring diagnostic bronchoscopic tissue sampling were included. TBLF and TBLC were both used for each patient in a randomized order. Histological assessment was undertaken on each biopsy and determined whether sarcoid was a consideration. Results: A histological diagnosis of sarcoidosis was established in 17 of 272 cases for which histopathology was available. In 6 out of 17 patients, compatible findings were seen with both TBLC and TBLF. In 10 patients, where the diagnosis of sarcoidosis was confirmed by TBLC, TBLF did not provide a diagnosis. In one patient, TBLF but not TBLC confirmed the diagnosis of sarcoidosis. Conclusions: In this post hoc analysis, the histological diagnosis of sarcoidosis was made significantly more often by TBLC than by TBLF. As in other idiopathic interstitial pneumonias (IIPs), the use of TBLC should be considered when sarcoidosis is suspected.

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 Dates: 2012-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3390/jcm10235686
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Title: Journal of Clinical Medicine
Source Genre: Journal
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Publ. Info: Basel : MDPI
Pages: 12 Volume / Issue: 10 (23) Sequence Number: 5686 Start / End Page: - Identifier: ISSN: 2077-0383
CoNE: https://pure.mpg.de/cone/journals/resource/2077-0383