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  GLINT: GlucoCEST in neoplastic tumors at 3 T-clinical results of GlucoCEST in gliomas

Bender, B., Herz, K., Deshmane, A., Richter, V., Tabatabai, G., Schittenhelm, J., et al. (2022). GLINT: GlucoCEST in neoplastic tumors at 3 T-clinical results of GlucoCEST in gliomas. Magnetic Resonance Materials in Physics, Biology and Medicine, 35(1), 77-85. doi:10.1007/s10334-021-00982-5.

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 Creators:
Bender, B, Author              
Herz, K1, 2, Author              
Deshmane, A1, 2, Author              
Richter, V, Author
Tabatabai , G, Author
Schittenhelm, J, Author
Skardelly, M, Author
Scheffler, K1, 2, Author              
Ernemann, U, Author
Kim, M, Author
Golay, X, Author
Zaiss, M1, 2, Author              
Lindig, T1, 2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Objective: Clinical relevance of dynamic glucose enhanced (DGE) chemical exchange saturation transfer (CEST) imaging has mostly been demonstrated at ultra-high field (UHF) due to low effect size. Results of a cohort study at clinical field strength are shown herein. Materials and methods: Motion and field inhomogeneity corrected T1ρ-based DGE (DGE⍴) images were acquired before, during and after a D-glucose injection with 6.3 s temporal resolution to detect accumulation in the brain. Six glioma patients with clear blood-brain barrier (BBB) leakage, two glioma patients with suspected BBB leakage, and three glioma patients without BBB leakage were scanned at 3 T. Results: In high-grade gliomas with BBB leakage, D-glucose uptake could be detected in the gadolinium (Gd) enhancing region as well as in the tumor necrosis with a maximum increase of ∆DGE⍴ around 0.25%, whereas unaffected white matter did not show any significant DGE⍴ increase. Glioma patients without Gd enhancement showed no detectable DGE⍴ effect within the tumor. Conclusion: First application of DGE⍴ in a patient cohort shows an association between BBB leakage and DGE signal irrespective of the tumor grade. This indicates that glucoCEST corresponds more to the disruptions of BBB with Gd uptake than to the molecular tumor profile or tumor grading.

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 Dates: 2021-122022-02
 Publication Status: Published in print
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 Identifiers: DOI: 10.1007/s10334-021-00982-5
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Title: Magnetic Resonance Materials in Physics, Biology and Medicine
Source Genre: Journal
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Publ. Info: Amsterdam : No longer published by Elsevier
Pages: - Volume / Issue: 35 (1) Sequence Number: - Start / End Page: 77 - 85 Identifier: ISSN: 0968-5243
CoNE: https://pure.mpg.de/cone/journals/resource/954926245532