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  GLINT: GlucoCEST in neoplastic tumors at 3 T-clinical results of GlucoCEST in gliomas

Bender, B., Herz, K., Deshmane, A., Richter, V., Tabatabai, G., Schittenhelm, J., et al. (2022). GLINT: GlucoCEST in neoplastic tumors at 3 T-clinical results of GlucoCEST in gliomas. Magnetic Resonance Materials in Physics, Biology and Medicine, 35(1), 77-85. doi:10.1007/s10334-021-00982-5.

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 Urheber:
Bender, B, Autor           
Herz, K1, 2, Autor           
Deshmane, A1, 2, Autor           
Richter, V, Autor
Tabatabai , G, Autor
Schittenhelm, J, Autor
Skardelly, M, Autor
Scheffler, K1, 2, Autor           
Ernemann, U, Autor
Kim, M, Autor
Golay, X, Autor
Zaiss, M1, 2, Autor           
Lindig, T1, 2, Autor           
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Zusammenfassung: Objective: Clinical relevance of dynamic glucose enhanced (DGE) chemical exchange saturation transfer (CEST) imaging has mostly been demonstrated at ultra-high field (UHF) due to low effect size. Results of a cohort study at clinical field strength are shown herein.

Materials and methods: Motion and field inhomogeneity corrected T1ρ-based DGE (DGE⍴) images were acquired before, during and after a D-glucose injection with 6.3 s temporal resolution to detect accumulation in the brain. Six glioma patients with clear blood-brain barrier (BBB) leakage, two glioma patients with suspected BBB leakage, and three glioma patients without BBB leakage were scanned at 3 T.

Results: In high-grade gliomas with BBB leakage, D-glucose uptake could be detected in the gadolinium (Gd) enhancing region as well as in the tumor necrosis with a maximum increase of ∆DGE⍴ around 0.25%, whereas unaffected white matter did not show any significant DGE⍴ increase. Glioma patients without Gd enhancement showed no detectable DGE⍴ effect within the tumor.

Conclusion: First application of DGE⍴ in a patient cohort shows an association between BBB leakage and DGE signal irrespective of the tumor grade. This indicates that glucoCEST corresponds more to the disruptions of BBB with Gd uptake than to the molecular tumor profile or tumor grading.

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 Datum: 2021-122022-02
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1007/s10334-021-00982-5
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Titel: Magnetic Resonance Materials in Physics, Biology and Medicine
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Amsterdam : No longer published by Elsevier
Seiten: - Band / Heft: 35 (1) Artikelnummer: - Start- / Endseite: 77 - 85 Identifikator: ISSN: 0968-5243
CoNE: https://pure.mpg.de/cone/journals/resource/954926245532