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  The Tangential Nucleus Controls a Gravito-inertial Vestibulo-ocular Reflex

Bianco, I., Ma, L.-H., Schoppik, D., Robson, D., Orger, M., Beck, J., et al. (2012). The Tangential Nucleus Controls a Gravito-inertial Vestibulo-ocular Reflex. Current Biology, 22(14), 1285-1295. doi:10.1016/j.cub.2012.05.026.

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Bianco, IH, Author
Ma, L-H, Author
Schoppik, D, Author
Robson, DN1, Author              
Orger, MB, Author
Beck, JC, Author
Li, JM1, Author              
Schier, AF, Author
Engert, F, Author
Baker, R, Author
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1External Organizations, ou_persistent22              

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 Abstract: Background Although adult vertebrates sense changes in head position by using two classes of accelerometer, at larval stages zebrafish lack functional semicircular canals and rely exclusively on their otolithic organs to transduce vestibular information. Results Despite this limitation, we find that larval zebrafish perform an effective vestibulo-ocular reflex (VOR) that serves to stabilize gaze in response to pitch and roll tilts. By using single-cell electroporations and targeted laser ablations, we identified a specific class of central vestibular neurons, located in the tangential nucleus, that are essential for the utricle-dependent VOR. Tangential nucleus neurons project contralaterally to extraocular motoneurons and in addition to multiple sites within the reticulospinal complex. Conclusions We propose that tangential neurons function as a broadband inertial accelerometer, processing utricular acceleration signals to control the activity of extraocular and postural neurons, thus completing a fundamental three-neuron circuit responsible for gaze stabilization. Highlights ► The utricle and its associated circuitry drive a broadband vestibular-ocular reflex ► Linear summation of bilateral utricular signals mediates compensatory eye rotations ► Central vestibular neurons in the tangential nucleus are necessary for the VOR ► Visual and vestibular signals interact to enhance gaze stabilization.

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 Dates: 2012-07
 Publication Status: Published in print
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1016/j.cub.2012.05.026
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Title: Current Biology
  Abbreviation : Curr. Biol.
Source Genre: Journal
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Publ. Info: London, UK : Cell Press
Pages: - Volume / Issue: 22 (14) Sequence Number: - Start / End Page: 1285 - 1295 Identifier: ISSN: 0960-9822
CoNE: https://pure.mpg.de/cone/journals/resource/954925579107