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  The Tangential Nucleus Controls a Gravito-inertial Vestibulo-ocular Reflex

Bianco, I., Ma, L.-H., Schoppik, D., Robson, D., Orger, M., Beck, J., et al. (2012). The Tangential Nucleus Controls a Gravito-inertial Vestibulo-ocular Reflex. Current Biology, 22(14), 1285-1295. doi:10.1016/j.cub.2012.05.026.

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Bianco, IH, Author
Ma, L-H, Author
Schoppik, D, Author
Robson, DN1, Author           
Orger, MB, Author
Beck, JC, Author
Li, JM1, Author           
Schier, AF, Author
Engert, F, Author
Baker, R, Author
Affiliations:
1External Organizations, ou_persistent22              

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 Abstract: Background

Although adult vertebrates sense changes in head position by using two classes of accelerometer, at larval stages zebrafish lack functional semicircular canals and rely exclusively on their otolithic organs to transduce vestibular information.
Results

Despite this limitation, we find that larval zebrafish perform an effective vestibulo-ocular reflex (VOR) that serves to stabilize gaze in response to pitch and roll tilts. By using single-cell electroporations and targeted laser ablations, we identified a specific class of central vestibular neurons, located in the tangential nucleus, that are essential for the utricle-dependent VOR. Tangential nucleus neurons project contralaterally to extraocular motoneurons and in addition to multiple sites within the reticulospinal complex.
Conclusions

We propose that tangential neurons function as a broadband inertial accelerometer, processing utricular acceleration signals to control the activity of extraocular and postural neurons, thus completing a fundamental three-neuron circuit responsible for gaze stabilization.
Highlights

► The utricle and its associated circuitry drive a broadband vestibular-ocular reflex ► Linear summation of bilateral utricular signals mediates compensatory eye rotations ► Central vestibular neurons in the tangential nucleus are necessary for the VOR ► Visual and vestibular signals interact to enhance gaze stabilization.

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 Dates: 2012-07
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1016/j.cub.2012.05.026
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Title: Current Biology
  Abbreviation : Curr. Biol.
Source Genre: Journal
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Publ. Info: London, UK : Cell Press
Pages: - Volume / Issue: 22 (14) Sequence Number: - Start / End Page: 1285 - 1295 Identifier: ISSN: 0960-9822
CoNE: https://pure.mpg.de/cone/journals/resource/954925579107