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  Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins

Nouvian, R., Neef, J., Bulankina, A. V., Reisinger, E., Pangrsic, T., Frank, T., et al. (2011). Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins. Nature Neuroscience, 14(4), 411-413. doi:10.1038/nn.2774.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0009-AF7E-6 Version Permalink: https://hdl.handle.net/21.11116/0000-0009-AF83-E
Genre: Journal Article

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 Creators:
Nouvian, R., Author
Neef, J., Author
Bulankina, A. V., Author
Reisinger, E., Author
Pangrsic, T., Author
Frank, Thomas1, Author           
Sikorra, S., Author
Brose, N., Author
Binz, T., Author
Moser, T., Author
Affiliations:
1Universität Göttingen, ou_persistent22              

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Free keywords: substrate recognition afferent synapse neuroexocytosis transmission endocytosis neurotoxins mouse Neurosciences & Neurology
 Abstract: SNARE proteins mediate membrane fusion. Neurosecretion depends on neuronal soluble NSF attachment protein receptors ( SNAREs; SNAP-25, syntaxin-1, and synaptobrevin-1 or synaptobrevin-2) and is blocked by neurotoxin-mediated cleavage or genetic ablation. We found that exocytosis in mouse inner hair cells (IHCs) was insensitive to neurotoxins and genetic ablation of neuronal SNAREs. mRNA, but no synaptically localized protein, of neuronal SNAREs was present in IHCs. Thus, IHC exocytosis is unconventional and may operate independently of neuronal SNAREs.

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Language(s): eng - English
 Dates: 2011
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000288849400007
DOI: 10.1038/nn.2774
ISSN: 1097-6256
 Degree: -

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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 14 (4) Sequence Number: - Start / End Page: 411 - 413 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931