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  Real-time imaging of brain activity in freely moving rats using functional ultrasound

Urban, A., Dussaux, C., Martel, G., Brunner, C., Macé, E., & Montaldo, G. (2015). Real-time imaging of brain activity in freely moving rats using functional ultrasound. Nature Methods, 12(9), 873-878. doi:10.1038/nmeth.3482.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0009-B0EE-4 Version Permalink: https://hdl.handle.net/21.11116/0000-000A-09C7-C
Genre: Journal Article

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 Creators:
Urban, A., Author
Dussaux, C., Author
Martel, G., Author
Brunner, C., Author
Macé, Emilie1, Author           
Montaldo, G., Author
Affiliations:
1Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, ou_persistent22              

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Free keywords: resolution awake connectivity oscillations responses Biochemistry & Molecular Biology
 Abstract: Innovative imaging methods help to investigate the complex relationship between brain activity and behavior in freely moving animals. Functional ultrasound (fUSUS) is an imaging modality suitable for recording cerebral blood volume (CBV) dynamics in the whole brain but has so far been used only in head-fixed and anesthetized rodents. We designed a fUSUS device for tethered brain imaging in freely moving rats based on a miniaturized ultrasound probe and a custom-made ultrasound scanner. We monitored CBV changes in rats during various behavioral states such as quiet rest, after whisker or visual stimulations, and in a food-reinforced operant task. We show that fUSUS imaging in freely moving rats could efficiently decode brain activity in real time.

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Language(s): eng - English
 Dates: 2015
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000360586700034
DOI: 10.1038/nmeth.3482
ISSN: 1548-7091
 Degree: -

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Title: Nature Methods
  Other : Nature Methods
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Nature Publishing Group
Pages: - Volume / Issue: 12 (9) Sequence Number: - Start / End Page: 873 - 878 Identifier: ISSN: 1548-7091
CoNE: https://pure.mpg.de/cone/journals/resource/111088195279556