English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Whole-brain functional ultrasound imaging reveals brain modules for visuomotor integration

Macé, E., Montaldo, G., Trenholm, S., Cowan, C., Brignall, A., Urban, A., et al. (2018). Whole-brain functional ultrasound imaging reveals brain modules for visuomotor integration. Neuron, 100(5), 1241-1251. doi:10.1016/j.neuron.2018.11.031.

Item is

Basic

show hide
Genre: Journal Article
Alternative Title : Whole- Brain Functional Ultrasound Imaging Reveals Brain Modules for Visuomotor Integration

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Macé, Emilie1, Author           
Montaldo, G., Author
Trenholm, S., Author
Cowan, C., Author
Brignall, A., Author
Urban, A., Author
Roska, B., Author
Affiliations:
1Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, ou_persistent22              

Content

show
hide
Free keywords: specialization activation origins neurons retina motion cortex cells maps bold Neurosciences & Neurology
 Abstract: Large numbers of brain regions are active during behaviors. A high-resolution, brain-wide activity map could identify brain regions involved in specific behaviors. We have developed functional ultrasound imaging to record whole-brain activity in behaving mice at a resolution of similar to 100 mm. We detected 87 active brain regions during visual stimulation that evoked the optokinetic reflex, a visuomotor behavior that stabilizes the gaze both horizontally and vertically. Using a genetic mouse model of congenital nystagmus incapable of generating the horizontal reflex, we identified a subset of regions whose activity was reflex dependent. By blocking eye motion in control animals, we further separated regions whose activity depended on the reflex's motor output. Remarkably, all reflex-dependent but eye motion-independent regions were located in the thalamus. Our work identifies functional modules of brain regions involved in sensorimotor integration and provides an experimental approach to monitor whole-brain activity of mice in normal and disease states.

Details

show
hide
Language(s): eng - English
 Dates: 2018
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000452295400023
DOI: 10.1016/j.neuron.2018.11.031
ISSN: 0896-6273
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Neuron
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 100 (5) Sequence Number: - Start / End Page: 1241 - 1251 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565