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  Wnt signaling mediates experience-related regulation of synapse numbers and mossy fiber connectivities in the adult hippocampus

Gogolla, N., Galimberti, I., Deguchi, Y., & Caroni, P. (2009). Wnt signaling mediates experience-related regulation of synapse numbers and mossy fiber connectivities in the adult hippocampus. Neuron, 62(4), 510-525. doi:10.1016/j.neuron.2009.04.022.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0009-B14A-C Versions-Permalink: https://hdl.handle.net/21.11116/0000-0009-B16E-4
Genre: Zeitschriftenartikel
Alternativer Titel : Wnt Signaling Mediates Experience-Related Regulation of Synapse Numbers and Mossy Fiber Connectivities in the Adult Hippocampus

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 Urheber:
Gogolla, Nadine1, Autor           
Galimberti, I., Autor
Deguchi, Y., Autor
Caroni, P., Autor
Affiliations:
1Friedrich Miescher Institut, Basel, Switzerland, ou_persistent22              

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Schlagwörter: pattern separation dentate gyrus rat hippocampus plasticity ca3 transmission terminals stress cells release Neurosciences & Neurology
 Zusammenfassung: We investigated how experience regulates the structure of a defined neuronal circuit in adult mice. Enriched environment (EE) produced a robust and reversible increase in hippocampal stratum lucidum synapse numbers, mossy fiber terminal (LMT) numbers, and spine plus synapse densities at LMTs, whereas a distinct mechanism depending on Rab3a promoted LMT volume growth. In parallel, EE increased postsynaptic CA3 pyramidal neuron Wnt7a/b levels. Inhibiting Writ signaling through locally applied sFRP-1 suppressed the effects of EE on synapse numbers and further reduced synapse numbers in control mice. Wnt7 applied to CA3 mimicked the effects of EE on synapse and LMT numbers. CA3 Wnt7a/b levels were enhanced by excitatory activity and reduced by sFRP-1. Synapse numbers and Wnt7a/b levels peaked in mice aged 6-12 months; a decline in aged mice was reversed by EE. Therefore, behavioral experience specifically regulates adult global stratum lucidum synapse numbers and hippocampal network structure through Writ signaling.

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Sprache(n): eng - English
 Datum: 2009
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: Anderer: WOS:000266619700008
DOI: 10.1016/j.neuron.2009.04.022
ISSN: 0896-6273
 Art des Abschluß: -

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Titel: Neuron
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Cambridge, Mass. : Cell Press
Seiten: - Band / Heft: 62 (4) Artikelnummer: - Start- / Endseite: 510 - 525 Identifikator: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565