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  Glycan microarrays containing synthetic Streptococcus pneumoniae CPS fragments and their application to vaccine development

Kaplonek, P., & Seeberger, P. H. (2022). Glycan microarrays containing synthetic Streptococcus pneumoniae CPS fragments and their application to vaccine development. In J. M. Walker (Ed.), Methods in Molecular Biology (pp. 193-206). New York: Springer. doi:10.1007/978-1-0716-2148-6_12.

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Article.pdf (Publisher version), 499KB
 
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 Creators:
Kaplonek, Paulina1, Author              
Seeberger, Peter H.1, Author              
Affiliations:
1Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308              

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Free keywords: Microbial glycans; Bacterial polysaccharides; Oligosaccharide microarrays; Polysaccharide fragments; Vaccines; Streptococcus pneumonia
 Abstract: Streptococcus pneumoniae is the leading source of life-endangering diseases like pneumonia, septicemia, and meningitis, as well as a major cause of death in children under 5 years old in developing countries. At least 98 serotypes of S. pneumoniae can be distinguished based on their structurally distinct capsular polysaccharides (CPS). Currently available CPS-based pneumococcal vaccines contain serotypes most frequently associated with invasive pneumococcal diseases. The polysaccharides used in commercial conjugate-vaccines are isolated from bacteria cultures comprising many laborious and operationally challenging steps followed by depolymerization of long polysaccharides into small fragments and their conjugation to the carrier protein. The medicinal chemistry approach for glycoconjugate vaccine development offers an exciting alternative to CPS isolation for a broad range of different glycan antigens. Glycan arrays containing well-defined synthetic glycans of CPS fragments and repeating units are used as a platform for the high-throughput screening of various serum samples and identification of protective glycotopes for vaccine candidates.

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Language(s): eng - English
 Dates: 2022-01-012022
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1007/978-1-0716-2148-6_12
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Title: Methods in Molecular Biology
Source Genre: Series
 Creator(s):
Walker, John M., Editor
Affiliations:
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Publ. Info: New York : Springer
Pages: - Volume / Issue: 2460 Sequence Number: - Start / End Page: 193 - 206 Identifier: ISSN: 1064-3745

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Title: Glycan microarrays : methods and protocols
Source Genre: Book
 Creator(s):
Kilcoyne, Michelle, Editor
Gerlach, Jared Q., Editor
Affiliations:
-
Publ. Info: New York : Humana
Pages: XI, 253 Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISBN: 978-1-0716-2148-6