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  Ongoing neural oscillations influence behavior and sensory representations by suppressing neuronal excitability

Iemi, L., Gwilliams, L., Samaha, J., Auksztulewicz, R., Cycowicz, Y. M., King, J.-R., et al. (2022). Ongoing neural oscillations influence behavior and sensory representations by suppressing neuronal excitability. NeuroImage, 247: 118746. doi:10.1016/j.neuroimage.2021.118746.

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 Creators:
Iemi, Luca1, 2, Author
Gwilliams, Laura3, Author
Samaha, Jason4, Author
Auksztulewicz, Ryszard5, 6, Author
Cycowicz, Yael M1, 2, Author
King, Jean-Remi7, Author
Nikulin, Vadim V.8, 9, Author              
Thesen, Thomas10, Author
Doyle, Werner10, Author
Devinsky, Orrin10, Author
Schroeder, Charles E1, 11, 12, Author
Melloni, Lucia5, 9, Author
Haegens, Saskia1, 2, 13, Author
Affiliations:
1Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA, ou_persistent22              
2New York State Psychiatric Institute, Columbia University Medical Center, New York, NY, USA, ou_persistent22              
3Department of Neurological Surgery, University of California, San Francisco, CA, USA, ou_persistent22              
4Department of Psychology, University of California, Santa Cruz, CA, USA, ou_persistent22              
5Department of Neuroscience, Max Planck Institute for Empirical Aesthetics, Frankfurt, Germany, ou_persistent22              
6Department of Neuroscience, Chinese University of Hong Kong, Hong Kong, China, ou_persistent22              
7Department d'etudes cognitives, École normale supérieure, Paris, France, ou_persistent22              
8Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
9Centre for Cognition and Decision Making, National Research University Higher School of Economics, Moscow, Russian, ou_persistent22              
10Department of Neurology, New York University Langone Medical Center, New York, NY, USA, ou_persistent22              
11Department of Neurological Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA, ou_persistent22              
12Translational Neuroscience Laboratories, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA, ou_persistent22              
13Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              

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Free keywords: Alpha; Prestimulus; Oscillations; Excitability; Reaction times; Decoding
 Abstract: The ability to process and respond to external input is critical for adaptive behavior. Why, then, do neural and behavioral responses vary across repeated presentations of the same sensory input? Ongoing fluctuations of neuronal excitability are currently hypothesized to underlie the trial-by-trial variability in sensory processing. To test this, we capitalized on intracranial electrophysiology in neurosurgical patients performing an auditory discrimination task with visual cues: specifically, we examined the interaction between prestimulus alpha oscillations, excitability, task performance, and decoded neural stimulus representations. We found that strong prestimulus oscillations in the alpha+ band (i.e., alpha and neighboring frequencies), rather than the aperiodic signal, correlated with a low excitability state, indexed by reduced broadband high-frequency activity. This state was related to slower reaction times and reduced neural stimulus encoding strength. We propose that the alpha+ rhythm modulates excitability, thereby resulting in variability in behavior and sensory representations despite identical input.

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Language(s): eng - English
 Dates: 2021-10-212021-07-092021-11-202021-12-042022-02-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuroimage.2021.118746
Other: online ahead print
PMID: 34875382
 Degree: -

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Project name : -
Grant ID : NWO 016.Vidi.185.137
Funding program : -
Funding organization : Netherlands Organization for Scientific Research
Project name : -
Grant ID : P50 MH109429
Funding program : -
Funding organization : Silvio O Conte Center for Active Sensing
Project name : -
Grant ID : 750459
Funding program : -
Funding organization : Marie Skłodowska-Curie Global Fellowship
Project name : -
Grant ID : 1R01EB019805, R01DA038154
Funding program : -
Funding organization : National Institute of Health

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 247 Sequence Number: 118746 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166