English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Dopamine enhances model-free credit assignment through boosting of retrospective model-based inference

Deserno, L., Moran, R., Michely, J., Lee, Y., Dayan, P., & Dolan, R. J. (2021). Dopamine enhances model-free credit assignment through boosting of retrospective model-based inference. eLife, 10: e67778. doi:10.7554/eLife.67778.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files

Locators

show
hide
Locator:
https://doi.org/10.7554/eLife.67778 (Publisher version)
Description:
-

Creators

show
hide
 Creators:
Deserno, Lorenz, Author
Moran, Rani1, Author              
Michely, Jochen, Author
Lee, Ying, Author
Dayan, Peter2, 3, Author
Dolan, Raymond J.1, Author              
Affiliations:
1Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany, and London, UK, Max Planck Institute for Human Development, Max Planck Society, ou_2205641              
2Department of Computational Neuroscience, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_3017468              
3Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: Dopamine is implicated in representing model-free (MF) reward prediction errors a as well as influencing model-based (MB) credit assignment and choice. Putative cooperative interactions between MB and MF systems include a guidance of MF credit assignment by MB inference. Here, we used a double-blind, placebo-controlled, within-subjects design to test an hypothesis that enhancing dopamine levels boosts the guidance of MF credit assignment by MB inference. In line with this, we found that levodopa enhanced guidance of MF credit assignment by MB inference, without impacting MF and MB influences directly. This drug effect correlated negatively with a dopamine-dependent change in purely MB credit assignment, possibly reflecting a trade-off between these two MB components of behavioural control. Our findings of a dopamine boost in MB inference guidance of MF learning highlights a novel DA influence on MB-MF cooperative interactions.

Details

show
hide
Language(s): eng - English
 Dates: 2021
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.7554/eLife.67778
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: eLife
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 10 Sequence Number: e67778 Start / End Page: - Identifier: -