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Free keywords:
Eph receptors
ephrins
morphogenesis
protein-tyrosine kinase
neural crest migration
retinal axon guidance
tumor-cell lines
transmembrane ligands
suggests roles
hindbrain
segmentation
rhombomere boundaries
molecular-cloning
commissural
axons
Developmental Biology
Abstract:
Eph receptor tyrosine kinases and their ligands, the ephrins, appear to lie functionally at the interface between pattern formation and morphogenesis. We review the role of Eph and ephrin signalling in the formation of segmented structures, in the control of axon guidance and cell migration and in the development of the vasculature. We address the question of how the specificity of response is achieved and discuss the specificity of ephrin-Eph interactions and the significance of structural domains in Eph receptors.
