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  Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube

Bergemann, A. D., Zhang, L., Chiang, M. K., Brambilla, R., Klein, R., & Flanagan, J. G. (1998). Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube. Oncogene, 16(4), 471-480. doi:10.1038/sj.onc.1201557.

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 Urheber:
Bergemann, A. D., Autor
Zhang, Lee, Autor
Chiang, M. K., Autor
Brambilla, R., Autor
Klein, Rüdiger1, Autor           
Flanagan, J. G., Autor
Affiliations:
1European Molecular Biology Laboratory, Heidelberg, ou_persistent22              

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Schlagwörter: Eph ephrin receptor kinase development neural protein-tyrosine kinase growth-factor floor plate kit-ligand transmembrane ligands molecular-cloning commissural axons messenger-rnas nervous-system in-vitro Biochemistry & Molecular Biology Oncology Cell Biology Genetics & Heredity
 Zusammenfassung: The ephrins are a family of ligands that bind to Eph family receptor tyrosine kinases, and have been implicated in axon guidance and other patterning processes during vertebrate development. We describe here the identification and characterization of murine ephrin-B3. The cDNA encodes a 340 amino acid transmembrane molecule, most closely related to the two other known transmembrane ligands, ephrin-B1 and ephrin-B2. In addition to homology in their extracellular receptor binding domains, these transmembrane ligands share striking homology between their cytoplasmic domains, with 31 of the last 34 amino acids of ephrin-B3 being identical to ephrin-B2, suggesting functional interactions of the cytoplasmic tail. While most Eph family ligands are promiscuous in their interactions with Eph receptors, binding studies with the five receptors known to bind other transmembrane ligands only revealed a high affinity interaction of ephrin-B3 with EphB3, with a dissociation constant of approximately 1 nM. In situ hybridization of mouse embryos showed ephrin-B3 is expressed prominently at the dorsal and ventral midline of the neural tube, particularly in the floor plate, a structure with key functions in patterning the nervous system. The isolation of this ligand may help to elucidate the molecular basis of patterning activities at the neural tube midline.

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Sprache(n): eng - English
 Datum: 1998
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: Anderer: WOS:000071739400005
DOI: 10.1038/sj.onc.1201557
ISSN: 0950-9232
 Art des Abschluß: -

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Titel: Oncogene
Genre der Quelle: Zeitschrift
 Urheber:
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Ort, Verlag, Ausgabe: Basingstoke, Hampshire, UK : Nature Publishing Group
Seiten: - Band / Heft: 16 (4) Artikelnummer: - Start- / Endseite: 471 - 480 Identifikator: ISSN: 0950-9232
CoNE: https://pure.mpg.de/cone/journals/resource/954925574955